Ciltacabtagene autoleucel for the treatment of multiple myeloma

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

While treatment options for multiple myeloma (MM) are continuing to expand, this disease remains one characterized by requiring multiple lines of therapy, with generally decreasing effectiveness of each subsequent line. The development of B-cell maturation antigen (BCMA)-directed chimeric antigen receptor (CAR) T-cell therapy has proven an exception to this rule. In the trial that led to approval of the BCMA CAR T-cell therapy ciltacabtagene autoleucel (cilta-cel) by the U.S. Food and Drug Administration (FDA), deep and durable response rates were observed in heavily pretreated patients. In this review we summarize the available clinical trial data for cilta-cel, including discussion on notable adverse events, as well as discuss ongoing studies that are likely to lead to paradigm changes in the management of MM. In addition, we discuss the issues that currently surround the real-world utilization of cilta-cel.

Original languageEnglish (US)
Pages (from-to)1-16
Number of pages16
JournalDrugs of Today
Volume59
Issue number1
DOIs
StatePublished - Jan 2023

Keywords

  • B-cell maturation antigen
  • Chimeric antigen receptor (CAR) T-cell therapy
  • Ciltacabtagene autoleucel
  • Hematologic malignancies
  • Multiple myeloma

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology

Fingerprint

Dive into the research topics of 'Ciltacabtagene autoleucel for the treatment of multiple myeloma'. Together they form a unique fingerprint.

Cite this