Circulating microRNA trafficking and regulation: Computational principles and practice

Juan Cui, Jiang Shu

Research output: Contribution to journalReview articlepeer-review

Abstract

Rapid advances in genomics discovery tools and a growing realization of microRNA's implication in intercellular communication have led to a proliferation of studies of circulating microRNA sorting and regulation across cells and different species. Although sometimes, reaching controversial scientific discoveries and conclusions, these studies have yielded new insights in the functional roles of circulating microRNA and a plethora of analytical methods and tools. Here, we consider this body of work in light of key computational principles underpinning discovery of circulating microRNAs in terms of their sorting and targeting, with the goal of providing practical guidance for applications that is focused on the design and analysis of circulating microRNAs and their context-dependent regulation. We survey a broad range of informatics methods and tools that are available to the researcher, discuss their key features, applications and various unsolved problems and close this review with prospects and broader implication of this field.

Original languageEnglish (US)
Pages (from-to)1313-1326
Number of pages14
JournalBriefings in bioinformatics
Volume21
Issue number4
DOIs
StatePublished - Jul 10 2019

Keywords

  • Circulating microRNA
  • Exosomal microRNA
  • Gene regulation network
  • MicroRNA sorting
  • MicroRNA target
  • Network analysis
  • RNA interactome
  • RNA motif

ASJC Scopus subject areas

  • Information Systems
  • Molecular Biology

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