Cisplatin-induced changes in bleomycin elimination

G. C. Yee; W. R. Crom; J. E. Champion; G. M. Brodeur; W. E. Evans

Cisplatin-induced changes in bleomycin elimination

G. C. Yee, W. R. Crom, J. E. Champion, G. M. Brodeur, W. E. Evans

Research output: Contribution to journal › Article › peer-review

Abstract

Bleomycin disposition was studied in two children who received at least six courses of vinblastine, bleomycin, and cisplatin. Total plasma clearance of bleomycin decreased from 39 to 18 ml/min/m², while the terminal-phase half-life increased from 4.4 to 6.0 hrs since the cumulative cisplatin dose was > 300 mg/m². In one patient, renal clearance of bleomycin decreased from 30 to 8.2 ml/min/m². Changes in serum creatinine on BUN were not predictive of changes in bleomycin elimination.

Original language	English (US)
Pages (from-to)	587-589
Number of pages	3
Journal	Cancer treatment reports
Volume	67
Issue number	6
State	Published - 1983
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

Cite this

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title = "Cisplatin-induced changes in bleomycin elimination",

abstract = "Bleomycin disposition was studied in two children who received at least six courses of vinblastine, bleomycin, and cisplatin. Total plasma clearance of bleomycin decreased from 39 to 18 ml/min/m2, while the terminal-phase half-life increased from 4.4 to 6.0 hrs since the cumulative cisplatin dose was > 300 mg/m2. In one patient, renal clearance of bleomycin decreased from 30 to 8.2 ml/min/m2. Changes in serum creatinine on BUN were not predictive of changes in bleomycin elimination.",

author = "Yee, {G. C.} and Crom, {W. R.} and Champion, {J. E.} and Brodeur, {G. M.} and Evans, {W. E.}",

year = "1983",

language = "English (US)",

volume = "67",

pages = "587--589",

journal = "Cancer treatment reports",

issn = "0361-5960",

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T1 - Cisplatin-induced changes in bleomycin elimination

AU - Yee, G. C.

AU - Crom, W. R.

AU - Champion, J. E.

AU - Brodeur, G. M.

AU - Evans, W. E.

PY - 1983

Y1 - 1983

N2 - Bleomycin disposition was studied in two children who received at least six courses of vinblastine, bleomycin, and cisplatin. Total plasma clearance of bleomycin decreased from 39 to 18 ml/min/m2, while the terminal-phase half-life increased from 4.4 to 6.0 hrs since the cumulative cisplatin dose was > 300 mg/m2. In one patient, renal clearance of bleomycin decreased from 30 to 8.2 ml/min/m2. Changes in serum creatinine on BUN were not predictive of changes in bleomycin elimination.

AB - Bleomycin disposition was studied in two children who received at least six courses of vinblastine, bleomycin, and cisplatin. Total plasma clearance of bleomycin decreased from 39 to 18 ml/min/m2, while the terminal-phase half-life increased from 4.4 to 6.0 hrs since the cumulative cisplatin dose was > 300 mg/m2. In one patient, renal clearance of bleomycin decreased from 30 to 8.2 ml/min/m2. Changes in serum creatinine on BUN were not predictive of changes in bleomycin elimination.

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M3 - Article

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JO - Cancer treatment reports

JF - Cancer treatment reports

IS - 6

ER -

Cisplatin-induced changes in bleomycin elimination

Abstract

ASJC Scopus subject areas

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