Cisplatin-induced changes in bleomycin elimination

G. C. Yee, W. R. Crom, J. E. Champion, G. M. Brodeur, W. E. Evans

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Bleomycin disposition was studied in two children who received at least six courses of vinblastine, bleomycin, and cisplatin. Total plasma clearance of bleomycin decreased from 39 to 18 ml/min/m2, while the terminal-phase half-life increased from 4.4 to 6.0 hrs since the cumulative cisplatin dose was > 300 mg/m2. In one patient, renal clearance of bleomycin decreased from 30 to 8.2 ml/min/m2. Changes in serum creatinine on BUN were not predictive of changes in bleomycin elimination.

Original languageEnglish (US)
Pages (from-to)587-589
Number of pages3
JournalCancer treatment reports
Volume67
Issue number6
StatePublished - 1983

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Yee, G. C., Crom, W. R., Champion, J. E., Brodeur, G. M., & Evans, W. E. (1983). Cisplatin-induced changes in bleomycin elimination. Cancer treatment reports, 67(6), 587-589.