Cisplatin-induced changes in bleomycin elimination

G. C. Yee, W. R. Crom, J. E. Champion, G. M. Brodeur, W. E. Evans

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Bleomycin disposition was studied in two children who received at least six courses of vinblastine, bleomycin, and cisplatin. Total plasma clearance of bleomycin decreased from 39 to 18 ml/min/m2, while the terminal-phase half-life increased from 4.4 to 6.0 hrs since the cumulative cisplatin dose was > 300 mg/m2. In one patient, renal clearance of bleomycin decreased from 30 to 8.2 ml/min/m2. Changes in serum creatinine on BUN were not predictive of changes in bleomycin elimination.

Original languageEnglish (US)
Pages (from-to)587-589
Number of pages3
JournalCancer treatment reports
Issue number6
StatePublished - 1983
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Cisplatin-induced changes in bleomycin elimination'. Together they form a unique fingerprint.

Cite this