Classifications of neural dendritic and synaptic damage resulting from HIV-1-associated dementia: A multiple criteria linear programming approach

Jialin Zheng, D. Erichsen, C. Williams, Hui Peng, Gang Kou, C. Shi, Yong Shi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

The ability to identify neuronal damage resulting from HIV-1-associated dementia (HAD) is crucial for designing specific therapies for the treatment of HAD. This paper proposes a two-class model of multiple criteria linear programming (MCLP) to classify the HAD neural dendritic and synaptic damages. The damages are measured by a number of quantitative variables such as the change of neuritis, arbors, branch nodes, and cell bodies. Given certain classes, including brain derived neurotrophic factor (BDNF) treatment, non-treatment, glutamate treatment, and gpl20 (HIV-1 envelop protein) from laboratory cell observations, we use the two-class MCLP model to learn the data patterns between two classes so that we can discover the knowledge about the HAD neural dendritic and synaptic damages under different treatments. This knowledge can be applied to design and study specific therapies for the prevention or reversal of the neuronal demise associated with HAD. In the paper, we first describe the technical background of the two-class models that includes concepts, modeling and computer algorithms. Then, we conduct a series of learning experimental tests on the data of laboratory cell observations. We also illustrate some significance and implications of learning results in the HAD research.

Original languageEnglish (US)
Title of host publicationProceedings of the 36th Annual Hawaii International Conference on System Sciences, HICSS 2003
EditorsRalph H. Sprague
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)0769518745, 9780769518749
DOIs
StatePublished - 2003
Event36th Annual Hawaii International Conference on System Sciences, HICSS 2003 - Big Island, United States
Duration: Jan 6 2003Jan 9 2003

Publication series

NameProceedings of the 36th Annual Hawaii International Conference on System Sciences, HICSS 2003

Other

Other36th Annual Hawaii International Conference on System Sciences, HICSS 2003
CountryUnited States
CityBig Island
Period1/6/031/9/03

ASJC Scopus subject areas

  • Information Systems
  • Computer Science Applications

Fingerprint Dive into the research topics of 'Classifications of neural dendritic and synaptic damage resulting from HIV-1-associated dementia: A multiple criteria linear programming approach'. Together they form a unique fingerprint.

  • Cite this

    Zheng, J., Erichsen, D., Williams, C., Peng, H., Kou, G., Shi, C., & Shi, Y. (2003). Classifications of neural dendritic and synaptic damage resulting from HIV-1-associated dementia: A multiple criteria linear programming approach. In R. H. Sprague (Ed.), Proceedings of the 36th Annual Hawaii International Conference on System Sciences, HICSS 2003 [1174806] (Proceedings of the 36th Annual Hawaii International Conference on System Sciences, HICSS 2003). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/HICSS.2003.1174806