TY - GEN
T1 - Classifying G protein-coupled receptors with multiple physicochemical properties
AU - Yang, Jingyi
AU - Deogun, Jitender
PY - 2008
Y1 - 2008
N2 - Automated annotation of G protein-coupled receptors (GPCRs) has been an intriguing topic because of the important role of GPCRs in pharmaceutical research. The diverse nature of GPCRs results in the lack of overall sequence homolog among members, making the classification of GPCRs a challenging task. In this paper, we propose a new method to classify GPCRs based on only their primary sequences. We extract feature vectors from protein sequences based on various physicochemical properties and use the Support Vector Machine (SVM) for the classification. When features derived from multiple properties are used together, we obtain the accuracy of 97.61% on GPCR Level I subfamily classification and 99.94% on GPCR superfamily recognition in double cross-validation tests. The results compare favorably with those reported in previous publications.
AB - Automated annotation of G protein-coupled receptors (GPCRs) has been an intriguing topic because of the important role of GPCRs in pharmaceutical research. The diverse nature of GPCRs results in the lack of overall sequence homolog among members, making the classification of GPCRs a challenging task. In this paper, we propose a new method to classify GPCRs based on only their primary sequences. We extract feature vectors from protein sequences based on various physicochemical properties and use the Support Vector Machine (SVM) for the classification. When features derived from multiple properties are used together, we obtain the accuracy of 97.61% on GPCR Level I subfamily classification and 99.94% on GPCR superfamily recognition in double cross-validation tests. The results compare favorably with those reported in previous publications.
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U2 - 10.1109/BMEI.2008.318
DO - 10.1109/BMEI.2008.318
M3 - Conference contribution
AN - SCOPUS:51549120989
SN - 9780769531182
T3 - BioMedical Engineering and Informatics: New Development and the Future - Proceedings of the 1st International Conference on BioMedical Engineering and Informatics, BMEI 2008
SP - 93
EP - 97
BT - BioMedical Engineering and Informatics
T2 - BioMedical Engineering and Informatics: New Development and the Future - 1st International Conference on BioMedical Engineering and Informatics, BMEI 2008
Y2 - 27 May 2008 through 30 May 2008
ER -