TY - JOUR
T1 - Clear-cell papulosis
T2 - A rare entity that may be misconstrued pathologically as normal skin
AU - Wysong, Ashley
AU - Sundram, Uma
AU - Benjamin, Latanya
PY - 2012/3
Y1 - 2012/3
N2 - We describe a case of multiple, discrete, hypopigmented macules in the suprapubic and axillary region in a healthy 3-year-old girl. The lesions first appeared at approximately 9 months of age and increased in number over time. Initial histopathologic examination by an outside dermatopathologist at 1 year of age was reported as showing nonspecific histologic changes. A repeat biopsy at 3 years of age showed large intraepidermal clear cells that expressed CKAE1/CAM5.2, CK7, and BRST2. These findings are diagnostic for clear-cell papulosis, a rare condition that primarily affects children. Without great clinical and pathologic suspicion, this is a diagnosis that can often be overlooked because the histologic findings are virtually identical to those of normal skin.
AB - We describe a case of multiple, discrete, hypopigmented macules in the suprapubic and axillary region in a healthy 3-year-old girl. The lesions first appeared at approximately 9 months of age and increased in number over time. Initial histopathologic examination by an outside dermatopathologist at 1 year of age was reported as showing nonspecific histologic changes. A repeat biopsy at 3 years of age showed large intraepidermal clear cells that expressed CKAE1/CAM5.2, CK7, and BRST2. These findings are diagnostic for clear-cell papulosis, a rare condition that primarily affects children. Without great clinical and pathologic suspicion, this is a diagnosis that can often be overlooked because the histologic findings are virtually identical to those of normal skin.
UR - http://www.scopus.com/inward/record.url?scp=84859103583&partnerID=8YFLogxK
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U2 - 10.1111/j.1525-1470.2011.01614.x
DO - 10.1111/j.1525-1470.2011.01614.x
M3 - Article
C2 - 22142549
AN - SCOPUS:84859103583
SN - 0736-8046
VL - 29
SP - 195
EP - 198
JO - Pediatric dermatology
JF - Pediatric dermatology
IS - 2
ER -