Click-connected ligand scaffolds: macrocyclic chelates for asymmetric hydrogenation

Zhang Qing, James M. Takacs

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


Click chemistry is used to construct ligand scaffolds for a series of chiral diphosphites. Enantioselectivity as high as 97% ee is obtained using these click ligands in rhodium-catalyzed asymmetric hydrogenation. Control experiments and spectroscopic data suggest that a 16-membered P,P-macrocyclic Rh(1) chelate is formed.

Original languageEnglish (US)
Pages (from-to)545-548
Number of pages4
JournalOrganic Letters
Issue number4
StatePublished - Feb 21 2008

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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