Click-connected ligand scaffolds: macrocyclic chelates for asymmetric hydrogenation

Zhang Qing; James M. Takacs

doi:10.1021/ol702890s

Click-connected ligand scaffolds: macrocyclic chelates for asymmetric hydrogenation

Zhang Qing, James M. Takacs

Chemistry

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Click chemistry is used to construct ligand scaffolds for a series of chiral diphosphites. Enantioselectivity as high as 97% ee is obtained using these click ligands in rhodium-catalyzed asymmetric hydrogenation. Control experiments and spectroscopic data suggest that a 16-membered P,P-macrocyclic Rh(1) chelate is formed.

Original language	English (US)
Pages (from-to)	545-548
Number of pages	4
Journal	Organic Letters
Volume	10
Issue number	4
DOIs	https://doi.org/10.1021/ol702890s
State	Published - Feb 21 2008

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol702890s

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title = "Click-connected ligand scaffolds: macrocyclic chelates for asymmetric hydrogenation",

abstract = "Click chemistry is used to construct ligand scaffolds for a series of chiral diphosphites. Enantioselectivity as high as 97% ee is obtained using these click ligands in rhodium-catalyzed asymmetric hydrogenation. Control experiments and spectroscopic data suggest that a 16-membered P,P-macrocyclic Rh(1) chelate is formed.",

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N2 - Click chemistry is used to construct ligand scaffolds for a series of chiral diphosphites. Enantioselectivity as high as 97% ee is obtained using these click ligands in rhodium-catalyzed asymmetric hydrogenation. Control experiments and spectroscopic data suggest that a 16-membered P,P-macrocyclic Rh(1) chelate is formed.

AB - Click chemistry is used to construct ligand scaffolds for a series of chiral diphosphites. Enantioselectivity as high as 97% ee is obtained using these click ligands in rhodium-catalyzed asymmetric hydrogenation. Control experiments and spectroscopic data suggest that a 16-membered P,P-macrocyclic Rh(1) chelate is formed.

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JO - Organic Letters

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ER -

Click-connected ligand scaffolds: macrocyclic chelates for asymmetric hydrogenation

Abstract

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