Clinical and pathological features of posttransplant lymphoproliferative disorders: Influence on survival and response to treatment

R. Hauke, B. Smir, T. Greiner, P. Bierman, S. Tarantolo, J. Anderson, B. Shaw, J. Armitage

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Purpose: To review the clinical and pathological characteristics of patients with posttransplant lymphoproliferative disorders (PTLD) occurring after solid organ transplantation and determine the influence of these characteristics on response to treatment and survival. Patients and methods: Retrospective review of 32 patients. Results: Overall five-year survival was 59%. Forty-five percent of patients diagnosed within the first year after transplant had advanced disease. Characteristics that were associated with poorer survival were diagnosis within the first year post-transplant, monoclonal tumors and presentation with an infectious mononucleosis-like syndrome. Six of eight patients treated with surgery are alive and disease-free. Conclusion: Patients with PTLD can achieve long-term survival. Surgery can play an important role in selected patients. Characteristics that may be associated with poorer survival are diagnosis within the first year after transplant, presence of a monoclonal tumor or an infectious mononucleosis-like presentation.

Original languageEnglish (US)
Pages (from-to)831-834
Number of pages4
JournalAnnals of Oncology
Volume12
Issue number6
DOIs
StatePublished - Jul 28 2001

Keywords

  • EBV
  • Lymphoproliferative
  • PTLD
  • Posttransplant
  • Transplantation

ASJC Scopus subject areas

  • Hematology
  • Oncology

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