Clinical biomarkers for Lewy body diseases

Mai M. Abdelmoaty, Eugene Lu, Rana Kadry, Emma G. Foster, Shaurav Bhattarai, R. Lee Mosley, Howard E. Gendelman

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Synucleinopathies are a group of neurodegenerative disorders characterized by pathologic aggregates of neural and glial α-synuclein (α-syn) in the form of Lewy bodies (LBs), Lewy neurites, and cytoplasmic inclusions in both neurons and glia. Two major classes of synucleinopathies are LB disease and multiple system atrophy. LB diseases include Parkinson’s disease (PD), PD with dementia, and dementia with LBs. All are increasing in prevalence. Effective diagnostics, disease-modifying therapies, and therapeutic monitoring are urgently needed. Diagnostics capable of differentiating LB diseases are based on signs and symptoms which might overlap. To date, no specific diagnostic test exists despite disease-specific pathologies. Diagnostics are aided by brain imaging and cerebrospinal fluid evaluations, but more accessible biomarkers remain in need. Mechanisms of α-syn evolution to pathologic oligomers and insoluble fibrils can provide one of a spectrum of biomarkers to link complex neural pathways to effective therapies. With these in mind, we review promising biomarkers linked to effective disease-modifying interventions.

Original languageEnglish (US)
Article number209
JournalCell and Bioscience
Volume13
Issue number1
DOIs
StatePublished - Dec 2023

Keywords

  • Biomarkers
  • Dementia with Lewy bodies
  • Parkinson’s disease
  • Parkinson’s disease with dementia
  • Synucleinopathies
  • α-synuclein

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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