TY - JOUR
T1 - Clinical consequences of contaminated blood cultures in adult hospitalized patients at an institution utilizing a rapid blood-culture identification system
AU - Liaquat, Sidra
AU - Baccaglini, Lorena
AU - Haynatzki, Gleb
AU - Medcalf, Sharon J.
AU - Rupp, Mark E.
N1 - Publisher Copyright:
© 2021 Cambridge University Press. All rights reserved.
PY - 2021/8
Y1 - 2021/8
N2 - Objective: To assess the clinical impact of contaminated blood cultures in hospitalized patients during a period when rapid diagnostic testing using a FilmArray Blood Culture Identification (BCID) panel was in use. Design: Retrospective cohort study. Setting: Single academic medical center. Participants: Patients who had blood culture(s) performed during an admission between June 2014 and December 2016. Methods: Length of hospital stay and days of antibiotic therapy were assessed in relation to blood-culture contamination using generalized linear models with univariable and multivariable analyses. Results: Among 11,474 patients who had blood cultures performed, the adjusted mean length of hospital stay for patients with contaminated blood-culture episodes (N = 464) was 12.3 days (95% confidence interval [CI], 11.4-13.2) compared to 11.5 days (95% CI, 11.0-11.9) for patients (N = 11,010) with negative blood-culture episodes (P =.032). The adjusted mean durations of antibiotic therapy for patients with contaminated and negative blood-culture episodes were 6.0 days (95% CI, 5.3-6.7) and 5.2 days (95% CI, 4.9-5.4), respectively (P =.011). Conclusions: Despite the use of molecular-based, rapid blood-culture identification, contamination of blood cultures continues to result in prolonged hospital stay and unnecessary antibiotic therapy in hospitalized patients.
AB - Objective: To assess the clinical impact of contaminated blood cultures in hospitalized patients during a period when rapid diagnostic testing using a FilmArray Blood Culture Identification (BCID) panel was in use. Design: Retrospective cohort study. Setting: Single academic medical center. Participants: Patients who had blood culture(s) performed during an admission between June 2014 and December 2016. Methods: Length of hospital stay and days of antibiotic therapy were assessed in relation to blood-culture contamination using generalized linear models with univariable and multivariable analyses. Results: Among 11,474 patients who had blood cultures performed, the adjusted mean length of hospital stay for patients with contaminated blood-culture episodes (N = 464) was 12.3 days (95% confidence interval [CI], 11.4-13.2) compared to 11.5 days (95% CI, 11.0-11.9) for patients (N = 11,010) with negative blood-culture episodes (P =.032). The adjusted mean durations of antibiotic therapy for patients with contaminated and negative blood-culture episodes were 6.0 days (95% CI, 5.3-6.7) and 5.2 days (95% CI, 4.9-5.4), respectively (P =.011). Conclusions: Despite the use of molecular-based, rapid blood-culture identification, contamination of blood cultures continues to result in prolonged hospital stay and unnecessary antibiotic therapy in hospitalized patients.
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U2 - 10.1017/ice.2020.1337
DO - 10.1017/ice.2020.1337
M3 - Article
C2 - 33298207
AN - SCOPUS:85097566542
SN - 0899-823X
VL - 42
SP - 978
EP - 984
JO - Infection Control and Hospital Epidemiology
JF - Infection Control and Hospital Epidemiology
IS - 8
ER -