Clinical effects and applications of the gut microbiome in hematologic malignancies

Christopher R. D’Angelo, Sailendharan Sudakaran, Natalie S. Callander

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

The gut microbiome and its effects on host immunity have exciting implications for cancer prognosis and therapy. Examples in allogeneic hematopoietic stem cell transplantation (allo-SCT) demonstrate the role of the gut microbiome as a biomarker for clinical outcomes, and animal models demonstrate how microbiota manipulation may augment therapeutic responses. There are multiple mechanisms that gut microbiota may have in affecting distant tumor environments, including control of cytokine release, dendritic cell activation, and T-cell lymphocyte stimulation. Recently, there has been a marked interest in understanding interactions between host and microbiome in hematologic malignancies. This review summarizes the current understanding of the gut microbiome and its impact on leukemia, lymphoma, multiple myeloma, and allo-SCT and highlights several broad methods for targeting the gut microbiome in therapeutic trials.

Original languageEnglish (US)
Pages (from-to)679-687
Number of pages9
JournalCancer
Volume127
Issue number5
DOIs
StatePublished - Mar 1 2021

Keywords

  • butyrate
  • gut microbiome
  • hematologic malignancies
  • review
  • translational research

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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