Hodgkin lymphoma can come to clinical attention in a variety of ways. These include symptoms caused by a growing mass and systemic symptoms that are presumably cytokine induced, and a diagnosis can be made incidentally as part of an evaluation for an unrelated problem. By far the most common presentation of Hodgkin lymphoma is the enlargement of lymph nodes that is typically painless and progressive. Although the most common place for lymph nodes to be found is in the neck and supraclavicular region, any lymph node-bearing area can be involved. Patients typically find enlarged nodes above the clavicle and seek medical attention when they do not regress, while physicians are relatively more likely to discover lymph nodes in other areas as part of a physical examination. Mediastinal lymphadenopathy is a particularly common finding in young women with Hodgkin lymphoma. This might be found incidentally on a chest X-ray or can be symptomatic. Although unusual, patients with Hodgkin lymphoma can present with superior vena cava syndrome, but chest pain and shortness of breath are more common symptoms caused by a large mediastinal mass. Lymphadenopathy found only below the diaphragm is more common in males and in elderly patients. Mesenteric lymphadenopathy is unusual in Hodgkin lymphoma. Retroperitoneal lymphadenopathy can be painful, but is more commonly asymptomatic and found on a staging evaluation or as part of the investigation to explain system symptoms such as fever, night sweats, or weight loss. Epitrochlear lymph node involvement is unusual in Hodgkin lymphoma.

Original languageEnglish (US)
Title of host publicationHodgkin Lymphoma
Subtitle of host publicationA Comprehensive Overview, Second Edition
PublisherSpringer International Publishing
Number of pages12
ISBN (Electronic)9783319125053
ISBN (Print)9783319125046
StatePublished - Jan 1 2015

ASJC Scopus subject areas

  • Medicine(all)


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