Clinical perspectives in primary nocturnal enuresis

Gretchen A. Gimpel, William J. Warzak, Brett R. Kuhn, John N. Walburn

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Primary nocturnal enuresis (PNE) is prevalent among the pediatric population, but not all professionals are aware of the current research regarding the etiology and treatment of this disorder. This paper presents a broad overview of PNE, including etiology and evaluation, with a specific emphasis on treatment issues. The most current treatments (imipramine, desmopressin acetate arginine vasopressin, enuresis alarms) are discussed, including recent research on their effectiveness. In considering the recent data on long-term efficacy, overall cost, and safety, the treatment of choice appears to be the enuresis alarm for those families who are capable of following protocols. Desmopressin acetate arginine vasopressin is a safe alternative that has the advantage of quick response and ease of administration.

Original languageEnglish (US)
Pages (from-to)23-30
Number of pages8
JournalClinical pediatrics
Issue number1
StatePublished - 1998

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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