Clinical profile and containment of the Ebola virus disease outbreak in two large West African cities, Nigeria, July–September 2014

Chima Ohuabunwo, Celestine Ameh, Oyin Oduyebo, Anthony Ahumibe, Bamidele Mutiu, Adebola Olayinka, Wasiu Gbadamosi, Erika Garcia, Carolina Nanclares, Wale Famiyesin, Abdulaziz Mohammed, Patrick Nguku, Richard I. Koko, Joshua Obasanya, Durojaye Adebayo, Yemi Gbadegesin, Oni Idigbe, Olukayode Oguntimehin, Sara Nyanti, Charles NzukiIsmail Abdus-Salam, Joseph Adeyemi, Nnanna Onyekwere, Emmanuel Musa, David Brett-Major, Faisal Shuaib, Abdulsalami Nasidi

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Introduction The Ebola virus disease (EVD) outbreak in Nigeria began when an infected diplomat from Liberia arrived in Lagos, the most populous city in Africa, with subsequent transmission to another large city. Methods First-, second-, and third-generation contacts were traced, monitored, and classified. Symptomatic contacts were managed at Ebola treatment centers as suspected, probable, and confirmed EVD cases using standard operating procedures adapted from the World Health Organization EVD guidelines. Reverse transcription PCR tests confirmed EVD. Socio-demographic, clinical, hospitalization, and outcome data of the July–September 2014 Nigeria EVD cohort were analyzed. Results The median age of the 20 EVD cases was 33 years (interquartile range 26–62 years). More females (55%), health workers (65%), and persons <40 years old (60%) were infected than males, non-health workers, and persons aged ≥40 years. No EVD case management worker contracted the disease. Presenting symptoms were fever (85%), fatigue (70%), and diarrhea (65%). Clinical syndromes were gastroenteritis (45%), hemorrhage (30%), and encephalopathy (15%). The case-fatality rate was 40% and there was one mental health complication. The average duration from symptom onset to presentation was 3 ± 2 days among survivors and 5 ± 2 days for non-survivors. The mean duration from symptom onset to discharge was 15 ± 5 days for survivors and 11 ± 2 days for non-survivors. Mortality was higher in the older age group, males, and those presenting late. Conclusion The EVD outbreak in Nigeria was characterized by the severe febrile gastroenteritis syndrome typical of the West African outbreak, better outcomes, rapid containment, and no infection among EVD care-providers. Early case detection, an effective incident management system, and prompt case management with on-site mobilization and training of local professionals were key to the outcome.

Original languageEnglish (US)
Pages (from-to)23-29
Number of pages7
JournalInternational Journal of Infectious Diseases
Volume53
DOIs
StatePublished - Dec 1 2016

Keywords

  • Clinical profile
  • Ebola virus disease
  • Gastroenteritis
  • Hemorrhagic fever
  • Nigeria
  • Outbreak containment

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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    Ohuabunwo, C., Ameh, C., Oduyebo, O., Ahumibe, A., Mutiu, B., Olayinka, A., Gbadamosi, W., Garcia, E., Nanclares, C., Famiyesin, W., Mohammed, A., Nguku, P., Koko, R. I., Obasanya, J., Adebayo, D., Gbadegesin, Y., Idigbe, O., Oguntimehin, O., Nyanti, S., ... Nasidi, A. (2016). Clinical profile and containment of the Ebola virus disease outbreak in two large West African cities, Nigeria, July–September 2014. International Journal of Infectious Diseases, 53, 23-29. https://doi.org/10.1016/j.ijid.2016.08.011