Clinical trials in multiple sclerosis: past, present, and future

Navid Manouchehri, Afsaneh Shirani, Victor H. Salinas, Lauren Tardo, Rehana Z. Hussain, David Pitt, Olaf Stuve

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


For the past four decades, multiple sclerosis (MS) has been a focus for clinical trial development and execution. Advances in translational neuroimmunology have led to the development of effective disease-modifying therapies (DMTs) that greatly benefit patients with MS and mitigate their burden of disease. These achievements also stem from continued progress made in the definition and discovery of sensitive disease diagnostic criteria, objective disability assessment scales, precise imaging techniques, and disease-specific biomarkers. As a result, our knowledge of MS pathophysiology is more mature; the established clinical practice for the diagnosis and management of MS could serve as a roadmap to guide the development of more disease-specific interventions. In this article we briefly review the main achievements in the evolution of clinical trials for MS, and discuss opportunities for improvements.

Original languageEnglish (US)
Pages (from-to)228-235
Number of pages8
JournalNeurologia i Neurochirurgia Polska
Issue number3
StatePublished - 2022


  • clinical trials
  • multiple sclerosis
  • pharmacology

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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