Clinical use of thymidine as a rescue agent from methotrexate toxicity

Jean L. Grem, Susan A. King, J. Mel Sorensen, Michaele C. Christian

Research output: Contribution to journalReview article

20 Scopus citations

Abstract

Thymidine has been available for clinical research as a rescue agent since 1978 under sponsorship of the Division of Cancer Treatment, National Cancer Institute. Renal insufficiency following administration of high dose methotrexate results in prolonged exposure to toxic concentrations of drug. Thymidine has been used in conjunction with leucovorin and alkaline hydration to protect patients with acute renal dysfunction from life-threatening methotrexate toxicity. The outcome of eight cases in which thymidine was released under the special exception mechanism to treat patients who developed acute renal failure following methotrexate are reported. The clinical trials using thymidine in combination with methotrexate in patients with normal renal function are also reviewed.

Original languageEnglish (US)
Pages (from-to)281-290
Number of pages10
JournalInvestigational New Drugs
Volume9
Issue number3
DOIs
StatePublished - Aug 1991

Keywords

  • high-dose methotrexate
  • thymidine rescue

ASJC Scopus subject areas

  • Oncology
  • Pharmacology
  • Pharmacology (medical)

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