Clinical utility of interferon gamma assay in the diagnosis of tuberculosis

Miguel G. Madariaga, Ziba Jalali, Susan Swindells

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations


Newly developed assays that measure the production of cellular interferon gamma are useful diagnostic tools for the diagnosis of tuberculosis and may potentially replace or complement the tuberculin skin test in some circumstances. Importantly, interferon gamma release assays are more specific than tuberculin skin tests. Unfortunately the tests do not differentiate between active or latent infection. In addition, immunocompromised patients are more likely to have indeterminate results. The current interferon gamma release assays test approved in the United States is costly and requires drawing blood and processing within 12 hours of collection. This study discusses the potential benefits and drawbacks in patients, including those who are immunocompromised.

Original languageEnglish (US)
Pages (from-to)540-547
Number of pages8
JournalJournal of the American Board of Family Medicine
Issue number6
StatePublished - Nov 2007

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Family Practice


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