Clinical validation of an algorithm for rapid and accurate automated segmentation of intracoronary optical coherence tomography images

Yiannis S. Chatzizisis, Vassilis G. Koutkias, Konstantinos Toutouzas, Andreas Giannopoulos, Ioanna Chouvarda, Maria Riga, Antonios P. Antoniadis, Grigorios Cheimariotis, Charalampos Doulaverakis, Ioannis Tsampoulatidis, Konstantina Bouki, Ioannis Kompatsiaris, Christodoulos Stefanadis, Nicos Maglaveras, George D. Giannoglou

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Objectives The analysis of intracoronary optical coherence tomography (OCT) images is based on manual identification of the lumen contours and relevant structures. However, manual image segmentation is a cumbersome and time-consuming process, subject to significant intra- and inter-observer variability. This study aims to present and validate a fully-automated method for segmentation of intracoronary OCT images. Methods We studied 20 coronary arteries (mean length = 39.7 ± 10.0 mm) from 20 patients who underwent a clinically-indicated cardiac catheterization. The OCT images (n = 1812) were segmented manually, as well as with a fully-automated approach. A semi-automated variation of the fully-automated algorithm was also applied. Using certain lumen size and lumen shape characteristics, the fully- and semi-automated segmentation algorithms were validated over manual segmentation, which was considered as the gold standard. Results Linear regression and Bland-Altman analysis demonstrated that both the fully-automated and semi-automated segmentation had a very high agreement with the manual segmentation, with the semi-automated approach being slightly more accurate than the fully-automated method. The fully-automated and semi-automated OCT segmentation reduced the analysis time by more than 97% and 86%, respectively, compared to manual segmentation. Conclusions In the current work we validated a fully-automated OCT segmentation algorithm, as well as a semi-automated variation of it in an extensive "real-life" dataset of OCT images. The study showed that our algorithm can perform rapid and reliable segmentation of OCT images.

Original languageEnglish (US)
Pages (from-to)568-580
Number of pages13
JournalInternational Journal of Cardiology
Issue number3
StatePublished - Apr 1 2014
Externally publishedYes


  • Image processing
  • Image segmentation
  • Method comparison study
  • Optical coherence tomography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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