Clonal chromosomal abnormalities in desmoid tumors. Implications for histopathogenesis

J. A. Bridge, C. Sreekantaiah, B. Mouron, J. R. Neff, A. A. Sandberg, S. R. Wolman

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123 Scopus citations

Abstract

Desmoid tumors (aggressive fibromatosis) are regarded as lesions of uncertain histopathogenesis. Cytogenetic analyses of 26 desmoid tumor specimens from abdominal or extraabdominal sites of 22 patients with or without Gardner's syndrome (GS) showed clonal karyotypic abnormalities in 7 cases, random abnormalities in 14 cases, and striking telomeric fusion in 5 cases. Loss of chromosome Y, a reported feature of fibromatosis in penile and palmar locations, was detected as a clonal aberration in two patients. Additionally, involvement of 5q was observed in six patients, two of whom had GS. Clonal interstitial deletions of 5q were observed in three patients, one with and two without GS. These findings confirm a clonal and probable neoplastic origin for desmoid tumor and suggest that abnormalities of the Y chromosome and 5q may be important in the genesis of this neoplasm.

Original languageEnglish (US)
Pages (from-to)430-436
Number of pages7
JournalCancer
Volume69
Issue number2
DOIs
StatePublished - Jan 15 1992

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Bridge, J. A., Sreekantaiah, C., Mouron, B., Neff, J. R., Sandberg, A. A., & Wolman, S. R. (1992). Clonal chromosomal abnormalities in desmoid tumors. Implications for histopathogenesis. Cancer, 69(2), 430-436. https://doi.org/10.1002/1097-0142(19920115)69:2<430::AID-CNCR2820690226>3.0.CO;2-H