Clonal selection of metastasis within the life history of a tumor

James E. Talmadge

Research output: Contribution to journalReview articlepeer-review

100 Scopus citations


In summary, this Point-Counterpoint has focused on the hypothesis of clonal selection and the need to study a metastatic hypothesis within the life history of a tumor. Further, we stress the criticality of studying metastasis using suitable models, experimental strategies, and protocols. In addition, the metastatic process needs to be studied in vivo and within the context of host-tumor interactions and the life history of a tumor, as well as orthotopic, spontaneous metastases (6, 8). Despite the controversy about the clonal selection hypothesis, we hope we have shown that this powerful hypothesis remains strongly supported by data and is even more relevant to tumor biology when viewed in light of the life history of tumors.

Original languageEnglish (US)
Pages (from-to)11471-11475
Number of pages5
JournalCancer Research
Issue number24
StatePublished - Dec 15 2007

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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