Clonorchicidal properties of the synthetic trioxolane OZ78

Jennifer Keiser, Shu Hua Xiao, Yuxiang Dongt, Jürg Utzinger, Jonathan L. Vennerstrom

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Because the synthetic trioxolane OZ78 is active against the liver fluke Fasciola hepatica, we were motivated to investigate the in vivo and in vitro activity against another liver fluke, namely Clonorchis sinensis. Rats infected with C. sinensis for 2 and 5 wk were treated orally with single doses of OZ78 (75, 150, or 300 mg/kg). Worm burden reductions were assessed against untreated control rats. Scanning electron microscopy (SEM) was used to observe adult C. sinensis after recovery from rats 1-3 days posttreatment with a single 300 mg/kg oral dose of OZ78 and after in vitro exposure to concentrations of 1, 10, and 100 μg/ml of OZ78. A single 300 mg/kg oral dose of OZ78 resulted in worm burden reductions of 78.5% and 98.5% against juvenile and adult C. sinensis, respectively. SEM observations revealed tegumental surface alterations, including blebbing and sloughing. OZ78 emerges as a new compound with a broad spectrum of activity against major foodborne trematode infections.

Original languageEnglish (US)
Pages (from-to)1208-1213
Number of pages6
JournalJournal of Parasitology
Volume93
Issue number5
DOIs
StatePublished - Oct 2007

ASJC Scopus subject areas

  • Parasitology
  • Ecology, Evolution, Behavior and Systematics

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