Clostridium difficile-associated infection: A disease of varying severity

Randeep S. Jawa, David W. Mercer

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Clostridium difficile-associated infection (CDI) can have varying severity from asymptomatic carriage to fulminant colitis. Its incidence and virulence in North America are increasing. The increase in virulence is associated with emergence of the highly toxigenic North American pulsed field gel electrophoresis-1 strain. The major risk factor for CDI is exposure to antibiotics. Another major risk factor is hospitalization. The spectrum of CDI ranges from asymptomatic carriers to fulminant disease. Although asymptomatic carriers require no treatment, fulminant disease carries a substantial mortality regardless of management strategy.

Original languageEnglish (US)
Pages (from-to)836-842
Number of pages7
JournalAmerican journal of surgery
Issue number6
StatePublished - Dec 2012


  • Antibiotics
  • Clostridium difficile
  • Colitis
  • Diarrhea
  • Thomas Orr lecture

ASJC Scopus subject areas

  • Surgery


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