CNS organoids: an innovative tool for neurological disease modeling and drug neurotoxicity screening

Tanya Chhibber, Sounak Bagchi, Behnaz Lahooti, Angela Verma, Abraham Al-Ahmad, Manash K. Paul, Gurudutt Pendyala, Rahul Dev Jayant

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

The paradigm of central nervous system (CNS) drug discovery has mostly relied on traditional approaches of rodent models or cell-based in vitro models. Owing to the issues of species differences between humans and rodents, it is difficult to correlate the robustness of data for neurodevelopmental studies. With advances in the stem-cell field, 3D CNS organoids have been developed and explored owing to their resemblance to the human brain architecture and functions. Further, CNS organoids provide a unique opportunity to mimic the human brain physiology and serve as a modeling tool to study the normal versus pathological brain or the elucidation of mechanisms of neurological disorders. Here, we discuss the recent application of a CNS organoid explored for neurodevelopment disease or a screening tool for CNS drug development.

Original languageEnglish (US)
Pages (from-to)456-465
Number of pages10
JournalDrug Discovery Today
Volume25
Issue number2
DOIs
StatePublished - Feb 2020

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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