@article{2af9dc83b0a5425f9fbfed71264a9687,
title = "CNS organoids: an innovative tool for neurological disease modeling and drug neurotoxicity screening",
abstract = "The paradigm of central nervous system (CNS) drug discovery has mostly relied on traditional approaches of rodent models or cell-based in vitro models. Owing to the issues of species differences between humans and rodents, it is difficult to correlate the robustness of data for neurodevelopmental studies. With advances in the stem-cell field, 3D CNS organoids have been developed and explored owing to their resemblance to the human brain architecture and functions. Further, CNS organoids provide a unique opportunity to mimic the human brain physiology and serve as a modeling tool to study the normal versus pathological brain or the elucidation of mechanisms of neurological disorders. Here, we discuss the recent application of a CNS organoid explored for neurodevelopment disease or a screening tool for CNS drug development.",
author = "Tanya Chhibber and Sounak Bagchi and Behnaz Lahooti and Angela Verma and Abraham Al-Ahmad and Paul, {Manash K.} and Gurudutt Pendyala and Jayant, {Rahul Dev}",
note = "Funding Information: R.D.J. would like to acknowledge the financial support from NIH (R03DA044877), The Campbell Foundation (Florida, USA) and SOP-Office of Science, Basic Science Pilot funding and start-up funds from the Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center (TTUHSC), TX, USA. GP acknowledges start-up funds from the Department of Anesthesiology, College of Medicine, University of Nebraska Medical Center (UNMC), Omaha, NE, USA. M.P. acknowledges Prof. Steven Dubinett and Prof. Brigitte Gomperts for providing the continuous financial support. Funding Information: R.D.J. would like to acknowledge the financial support from NIH ( R03DA044877 ), The Campbell Foundation (Florida, USA) and SOP-Office of Science, Basic Science Pilot funding and start-up funds from the Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center (TTUHSC), TX, USA . GP acknowledges start-up funds from the Department of Anesthesiology, College of Medicine , University of Nebraska Medical Center (UNMC), Omaha, NE, USA. M.P. acknowledges Prof. Steven Dubinett and Prof. Brigitte Gomperts for providing the continuous financial support. Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",
year = "2020",
month = feb,
doi = "10.1016/j.drudis.2019.11.010",
language = "English (US)",
volume = "25",
pages = "456--465",
journal = "Drug Discovery Today",
issn = "1359-6446",
publisher = "Elsevier Limited",
number = "2",
}