@article{97f249807602448881fc47fb5e7fc0e6,
title = "Coadministration of liposomal amphotericin B and contrast medium does not increase risk of kidney injury",
abstract = "Intravenous radiographic contrast medium and amphotericin B are commonly required in the care of patients with fungal infections. Both interventions have proposed nephrotoxicity through similar mechanisms. We systematically examined patients who received coadministration of liposomal amphotericin B (AmBisome; GE Healthcare) and intravenous contrast medium within a 24-h period and compared the results for those patients with the results for patients who underwent noncontrast medium studies. We found 114 cases and 85 controls during our study period. Overall, no increased risk of renal injury was seen with coadministration of these 2 agents. Adjustment for age, baseline kidney function, and other clinical factors through propensity score adjustment did not change this result. Our observations suggest that, when clinically indicated, coadministration of contrast medium and liposomal amphotericin B does not present excess risk compared with that from the administration of liposomal amphotericin B alone.",
keywords = "Computed tomography, Invasive fungal infection, Kidney injury",
author = "O{\textquoteright}Horo, {John C.} and Osmon, {Douglas R.} and {Abu Saleh}, {Omar M.} and Marcelin, {Jasmine R.} and Gharaibeh, {Kamel A.} and Hamadah, {Abdurrahman M.} and Barwise, {Amelia K.} and Kayhart, {Bryce M.} and McDonald, {Jennifer S.} and McDonald, {Robert J.} and Nelson Leung",
note = "Funding Information: John C. O{\textquoteright}Horo worked on the study design, conducted analyses, and contributed to manuscript preparation. Douglas R. Osmon contributed to study design and manuscript preparation. Omar M. Abu Saleh, Jasmine R. Marcelin, Kamel A. Gharaibeh, Abdurrahman M. Hamadah, and Amelia K. Barwise contributed to data collection and analysis. Bryce M. Kayhart contributed to data analysis and manuscript preparation. Jennifer S. McDonald, Robert J. McDonald, and Nelson Leung contributed to study design, data analysis, and manuscript preparation. None of the authors has any conflicts of interest to disclose. Jennifer S. McDonald has an investigator-initiated grant with GE Healthcare, independent of the present study, regarding contrast agent nephropathy. This project is in part supported by grant number UL1 TR000135 from the National Center for Advancing Translational Sciences (NCATS). This publication was made possible by funding from the Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery. The contents of this article are solely the responsibility of the authors and do not necessarily represent the official views of the National Institutes of Health. None of the funders had any role in study design, data collection, interpretation, or the decision to submit the work for publication. Mayo Clinic does not endorse specific products or services included in this article. Publisher Copyright: {\textcopyright} 2017 American Society for Microbiology. All Rights Reserved.",
year = "2017",
month = aug,
doi = "10.1128/AAC.00323-17",
language = "English (US)",
volume = "61",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "8",
}