Coagulase-Negative Staphylococcal Infections

Kathie L. Rogers; Paul D. Fey; Mark E. Rupp

doi:10.1016/j.idc.2008.10.001

Coagulase-Negative Staphylococcal Infections

Kathie L. Rogers, Paul D. Fey, Mark E. Rupp

Research output: Contribution to journal › Review article › peer-review

311 Scopus citations

Abstract

Coagulase-negative staphylococci (CNS) are differentiated from the closely related but more virulent Staphylococcus aureus by their inability to produce free coagulase. Currently, there are over 40 recognized species of CNS. These organisms typically reside on healthy human skin and mucus membranes, rarely cause disease, and are most frequently encountered by clinicians as contaminants of microbiological cultures. However, CNS have been increasingly recognized to cause clinically significant infections. The conversion of the CNS from symbiont to human pathogen has been a direct reflection of the use of indwelling medical devices. This article deals with the clinical syndromes, epidemiology, prevention, and management of infections caused by this unique group of organisms.

Original language	English (US)
Pages (from-to)	73-98
Number of pages	26
Journal	Infectious disease clinics of North America
Volume	23
Issue number	1
DOIs	https://doi.org/10.1016/j.idc.2008.10.001
State	Published - Mar 2009

Keywords

Biofilm
Coagulase-negative Staphylococci
Intravascular catheter-associated bloodstream infection
Prosthetic device infection
Staphylococcus epidermidis
Staphylococcus haemolyticus
Staphylococcus saprophyticus

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1016/j.idc.2008.10.001

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title = "Coagulase-Negative Staphylococcal Infections",

abstract = "Coagulase-negative staphylococci (CNS) are differentiated from the closely related but more virulent Staphylococcus aureus by their inability to produce free coagulase. Currently, there are over 40 recognized species of CNS. These organisms typically reside on healthy human skin and mucus membranes, rarely cause disease, and are most frequently encountered by clinicians as contaminants of microbiological cultures. However, CNS have been increasingly recognized to cause clinically significant infections. The conversion of the CNS from symbiont to human pathogen has been a direct reflection of the use of indwelling medical devices. This article deals with the clinical syndromes, epidemiology, prevention, and management of infections caused by this unique group of organisms.",

keywords = "Biofilm, Coagulase-negative Staphylococci, Intravascular catheter-associated bloodstream infection, Prosthetic device infection, Staphylococcus epidermidis, Staphylococcus haemolyticus, Staphylococcus saprophyticus",

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AU - Fey, Paul D.

AU - Rupp, Mark E.

PY - 2009/3

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N2 - Coagulase-negative staphylococci (CNS) are differentiated from the closely related but more virulent Staphylococcus aureus by their inability to produce free coagulase. Currently, there are over 40 recognized species of CNS. These organisms typically reside on healthy human skin and mucus membranes, rarely cause disease, and are most frequently encountered by clinicians as contaminants of microbiological cultures. However, CNS have been increasingly recognized to cause clinically significant infections. The conversion of the CNS from symbiont to human pathogen has been a direct reflection of the use of indwelling medical devices. This article deals with the clinical syndromes, epidemiology, prevention, and management of infections caused by this unique group of organisms.

AB - Coagulase-negative staphylococci (CNS) are differentiated from the closely related but more virulent Staphylococcus aureus by their inability to produce free coagulase. Currently, there are over 40 recognized species of CNS. These organisms typically reside on healthy human skin and mucus membranes, rarely cause disease, and are most frequently encountered by clinicians as contaminants of microbiological cultures. However, CNS have been increasingly recognized to cause clinically significant infections. The conversion of the CNS from symbiont to human pathogen has been a direct reflection of the use of indwelling medical devices. This article deals with the clinical syndromes, epidemiology, prevention, and management of infections caused by this unique group of organisms.

KW - Biofilm

KW - Coagulase-negative Staphylococci

KW - Intravascular catheter-associated bloodstream infection

KW - Prosthetic device infection

KW - Staphylococcus epidermidis

KW - Staphylococcus haemolyticus

KW - Staphylococcus saprophyticus

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JO - Infectious Disease Clinics of North America

JF - Infectious Disease Clinics of North America

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Coagulase-Negative Staphylococcal Infections

Abstract

Keywords

ASJC Scopus subject areas

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