Cocaine abuse and HIV-1 infection: Epidemiology and neuropathogenesis

Karl Goodkin, Paul Shapshak, Lisa R. Metsch, Clyde B. McCoy, Keith A. Crandall, Mahendra Kumar, Robert K. Fujimura, Virginia McCoy, Bao Tong Zhang, Svetlana Reyblat, Ke Qin Xin, Adarsh M. Kumar

Research output: Contribution to journalArticle

55 Scopus citations

Abstract

The epidemiology of cocaine abuse and potential relationships of cocaine withdrawal to human immunodeficiency virus type 1 (HIV-1)-associated dementia (HAD) are discussed. Neuroendocrinological changes in HIV-1 infection of the central nervous system (CNS) are discussed with the relevant impact of cocaine abuse. HIV-1 load in the brain tissue of infected substance users is described along with possible associations with neuropathology and HAD. Finally, the molecular epidemiology and sequence heterogeneity of HIV-1 and their implications for neuropathogenesis are summarized. The complex context of addressing cocaine abuse in the setting of HIV-1 infection appears more tractable when decomposed into its components.

Original languageEnglish (US)
Pages (from-to)88-101
Number of pages14
JournalJournal of Neuroimmunology
Volume83
Issue number1-2
DOIs
StatePublished - Mar 15 1998

Keywords

  • AIDS
  • Cocaine withdrawal
  • HIV-1
  • HIV-1-associated dementia (HAD)
  • Substance abuse
  • Virus load

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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  • Cite this

    Goodkin, K., Shapshak, P., Metsch, L. R., McCoy, C. B., Crandall, K. A., Kumar, M., Fujimura, R. K., McCoy, V., Zhang, B. T., Reyblat, S., Xin, K. Q., & Kumar, A. M. (1998). Cocaine abuse and HIV-1 infection: Epidemiology and neuropathogenesis. Journal of Neuroimmunology, 83(1-2), 88-101. https://doi.org/10.1016/S0165-5728(97)00225-7