Cognitive control of attention is differentially affected in trauma-exposed individuals with and without post-traumatic stress disorder

K. S. Blair, M. Vythilingam, S. L. Crowe, D. E. McCaffrey, P. Ng, C. C. Wu, M. Scaramozza, K. Mondillo, D. S. Pine, D. S. Charney, R. J.R. Blair

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

Background This study aimed to determine whether patients with post-traumatic stress disorder (PTSD) show difficulty in recruitment of the regions of the frontal and parietal cortex implicated in top-down attentional control in the presence and absence of emotional distracters. Method Unmedicated individuals with PTSD (n = 14), and age-, IQ-and gender-matched individuals exposed to trauma (n = 15) and healthy controls (n = 19) were tested on the affective number Stroop task. In addition, blood oxygen level-dependent responses, as measured via functional magnetic resonance imaging, were recorded. Results Patients with PTSD showed disrupted recruitment of lateral regions of the superior and inferior frontal cortex as well as the parietal cortex in the presence of negative distracters. Trauma-comparison individuals showed indications of a heightened ability to recruit fronto-parietal regions implicated in top-down attentional control across distracter conditions. Conclusions These results are consistent with suggestions that emotional responsiveness can interfere with the recruitment of regions implicated in top-down attentional control; the heightened emotional responding of patients with PTSD may lead to the heightened interference in the recruitment of these regions.

Original languageEnglish (US)
Pages (from-to)85-95
Number of pages11
JournalPsychological medicine
Volume43
Issue number1
DOIs
StatePublished - Jan 1 2013

Keywords

  • Anxiety
  • fMRI
  • fronto-parietal cortex
  • post-traumatic stress disorder
  • top down attention control

ASJC Scopus subject areas

  • Applied Psychology
  • Psychiatry and Mental health

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    Blair, K. S., Vythilingam, M., Crowe, S. L., McCaffrey, D. E., Ng, P., Wu, C. C., Scaramozza, M., Mondillo, K., Pine, D. S., Charney, D. S., & Blair, R. J. R. (2013). Cognitive control of attention is differentially affected in trauma-exposed individuals with and without post-traumatic stress disorder. Psychological medicine, 43(1), 85-95. https://doi.org/10.1017/S0033291712000840