Cognitive dysfunction in major depression and Alzheimer’s disease is associated with hippocampal–prefrontal cortex dysconnectivity

Dayalan Sampath, Monica Sathyanesan, Samuel S. Newton

Research output: Contribution to journalReview article

33 Scopus citations

Abstract

Cognitive dysfunction is prevalent in psychiatric disorders. Deficits are observed in multiple domains, including working memory, executive function, attention, and information processing. Disability caused by cognitive dysfunction is frequently as debilitating as the prominent emotional disturbances. Interactions between the hippocampus and the prefrontal cortex are increasingly appreciated as an important link between cognition and emotion. Recent developments in optogenetics, imaging, and connectomics can enable the investigation of this circuit in a manner that is relevant to disease pathophysiology. The goal of this review is to shed light on the contributions of this circuit to cognitive dysfunction in neuropsychiatric disorders, focusing on Alzheimer’s disease and depression.

Original languageEnglish (US)
Pages (from-to)1509-1519
Number of pages11
JournalNeuropsychiatric Disease and Treatment
Volume13
DOIs
StatePublished - Jun 12 2017

Keywords

  • Alzheimer’s disease
  • Cognition
  • Depression
  • Hippocampus
  • Prefrontal cortex

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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