TY - JOUR
T1 - Cognitive functioning in younger and older HIV-1-infected adults
AU - Wilkie, Frances L.
AU - Goodkin, Karl
AU - Khamis, Imad
AU - Van Zuilen, Maria H.
AU - Lee, Diana
AU - Lecusay, Robert
AU - Concha, Mauricio
AU - Symes, Stephen
AU - Suarez, Paola
AU - Eisdorfer, Carl
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2003/6/1
Y1 - 2003/6/1
N2 - In young adults, a major neurologic complication of HIV-1 infection is cognitive motor impairment. Epidemiologic findings suggest that increasing age is a significant risk factor for HIV-1 - associated dementia as the AIDS-defining illness. Findings from the few studies that have directly measured cognition in younger and older HIV-1 - infected adults, however, have been mixed, in part, because of small sample sizes and other methodologic differences between studies. The authors present preliminary findings on cognitive functioning in symptomatic HIV-1 - infected younger (aged 20-39 years) and older (aged 50 years or older) adults. Independent of age, HIV-1 infection was accompanied by learning and memory retrieval deficits, which were significantly associated with high plasma viral loads in the young adults. Relative to the younger and older HIV-1-negative (HIV-I-) groups, only the younger HIV-1-positive (HIV-1+) group had significantly longer reaction times (RTs). Within the older HIV-1+ group, however, longer simple and choice RTs were significantly correlated with higher viral loads and lower CD4 cell counts. Although HIV-1 infection affects cognition independent of age, longitudinal studies involving large numbers of older individuals are needed to determine whether there are age differences in the prevalence, nature, and severity of HIV-1-associated cognitive dysfunction.
AB - In young adults, a major neurologic complication of HIV-1 infection is cognitive motor impairment. Epidemiologic findings suggest that increasing age is a significant risk factor for HIV-1 - associated dementia as the AIDS-defining illness. Findings from the few studies that have directly measured cognition in younger and older HIV-1 - infected adults, however, have been mixed, in part, because of small sample sizes and other methodologic differences between studies. The authors present preliminary findings on cognitive functioning in symptomatic HIV-1 - infected younger (aged 20-39 years) and older (aged 50 years or older) adults. Independent of age, HIV-1 infection was accompanied by learning and memory retrieval deficits, which were significantly associated with high plasma viral loads in the young adults. Relative to the younger and older HIV-1-negative (HIV-I-) groups, only the younger HIV-1-positive (HIV-1+) group had significantly longer reaction times (RTs). Within the older HIV-1+ group, however, longer simple and choice RTs were significantly correlated with higher viral loads and lower CD4 cell counts. Although HIV-1 infection affects cognition independent of age, longitudinal studies involving large numbers of older individuals are needed to determine whether there are age differences in the prevalence, nature, and severity of HIV-1-associated cognitive dysfunction.
KW - Aging
KW - CD4 cell count
KW - Cognition
KW - HIV-1 infection
KW - Neuropsychology
KW - Viral load
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U2 - 10.1097/00126334-200306012-00006
DO - 10.1097/00126334-200306012-00006
M3 - Article
C2 - 12853858
AN - SCOPUS:0038003160
SN - 1525-4135
VL - 33
SP - S93-S105
JO - Journal of Acquired Immune Deficiency Syndromes
JF - Journal of Acquired Immune Deficiency Syndromes
IS - SUPPL. 2
ER -