Colorectal cancer: Review of signaling pathways and associated therapeutic strategies

Premila D. Leiphrakpam, Senthil J. Rajappa, Mridula Krishnan, Rishi Batra, Shilpa S. Murthy, Chandrakanth Are

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Tumor profiling and targeted therapy revolutionized the treatment strategies of metastatic colorectal cancer (mCRC) in the last decade. The heterogeneity of CRC tumors plays a critical role in the development of treatment resistance, which underscores the need to understand the molecular mechanism involved in CRC to develop novel targeted therapeutic strategies. This review provides an overview of the signaling pathways driving CRC, the existing targeted agents, their limitations, and future trends.

Original languageEnglish (US)
Pages (from-to)1277-1295
Number of pages19
JournalJournal of Surgical Oncology
Volume127
Issue number8
DOIs
StatePublished - Jun 15 2023

Keywords

  • biomarkers
  • colorectal cancer
  • targeted therapy

ASJC Scopus subject areas

  • Surgery
  • Oncology

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