Colorectal cancer: Review of signaling pathways and associated therapeutic strategies

Premila D. Leiphrakpam; Senthil J. Rajappa; Mridula Krishnan; Rishi Batra; Shilpa S. Murthy; Chandrakanth Are

doi:10.1002/jso.27295

Colorectal cancer: Review of signaling pathways and associated therapeutic strategies

Premila D. Leiphrakpam, Senthil J. Rajappa, Mridula Krishnan, Rishi Batra, Shilpa S. Murthy, Chandrakanth Are

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Tumor profiling and targeted therapy revolutionized the treatment strategies of metastatic colorectal cancer (mCRC) in the last decade. The heterogeneity of CRC tumors plays a critical role in the development of treatment resistance, which underscores the need to understand the molecular mechanism involved in CRC to develop novel targeted therapeutic strategies. This review provides an overview of the signaling pathways driving CRC, the existing targeted agents, their limitations, and future trends.

Original language	English (US)
Pages (from-to)	1277-1295
Number of pages	19
Journal	Journal of Surgical Oncology
Volume	127
Issue number	8
DOIs	https://doi.org/10.1002/jso.27295
State	Published - Jun 15 2023

Keywords

biomarkers
colorectal cancer
targeted therapy

ASJC Scopus subject areas

Surgery
Oncology

Access to Document

10.1002/jso.27295

Cite this

@article{f776a5dbbf3943eabb519f767888f0e9,

title = "Colorectal cancer: Review of signaling pathways and associated therapeutic strategies",

abstract = "Tumor profiling and targeted therapy revolutionized the treatment strategies of metastatic colorectal cancer (mCRC) in the last decade. The heterogeneity of CRC tumors plays a critical role in the development of treatment resistance, which underscores the need to understand the molecular mechanism involved in CRC to develop novel targeted therapeutic strategies. This review provides an overview of the signaling pathways driving CRC, the existing targeted agents, their limitations, and future trends.",

keywords = "biomarkers, colorectal cancer, targeted therapy",

author = "Leiphrakpam, {Premila D.} and Rajappa, {Senthil J.} and Mridula Krishnan and Rishi Batra and Murthy, {Shilpa S.} and Chandrakanth Are",

note = "Publisher Copyright: {\textcopyright} 2023 Wiley Periodicals LLC.",

year = "2023",

month = jun,

day = "15",

doi = "10.1002/jso.27295",

language = "English (US)",

volume = "127",

pages = "1277--1295",

journal = "Journal of Surgical Oncology",

issn = "0022-4790",

publisher = "Wiley-Liss Inc.",

number = "8",

}

TY - JOUR

T1 - Colorectal cancer

T2 - Review of signaling pathways and associated therapeutic strategies

AU - Leiphrakpam, Premila D.

AU - Rajappa, Senthil J.

AU - Krishnan, Mridula

AU - Batra, Rishi

AU - Murthy, Shilpa S.

AU - Are, Chandrakanth

PY - 2023/6/15

Y1 - 2023/6/15

N2 - Tumor profiling and targeted therapy revolutionized the treatment strategies of metastatic colorectal cancer (mCRC) in the last decade. The heterogeneity of CRC tumors plays a critical role in the development of treatment resistance, which underscores the need to understand the molecular mechanism involved in CRC to develop novel targeted therapeutic strategies. This review provides an overview of the signaling pathways driving CRC, the existing targeted agents, their limitations, and future trends.

AB - Tumor profiling and targeted therapy revolutionized the treatment strategies of metastatic colorectal cancer (mCRC) in the last decade. The heterogeneity of CRC tumors plays a critical role in the development of treatment resistance, which underscores the need to understand the molecular mechanism involved in CRC to develop novel targeted therapeutic strategies. This review provides an overview of the signaling pathways driving CRC, the existing targeted agents, their limitations, and future trends.

KW - biomarkers

KW - colorectal cancer

KW - targeted therapy

UR - http://www.scopus.com/inward/record.url?scp=85159930637&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85159930637&partnerID=8YFLogxK

U2 - 10.1002/jso.27295

DO - 10.1002/jso.27295

M3 - Review article

C2 - 37222698

AN - SCOPUS:85159930637

SN - 0022-4790

VL - 127

SP - 1277

EP - 1295

JO - Journal of Surgical Oncology

JF - Journal of Surgical Oncology

IS - 8

ER -

Colorectal cancer: Review of signaling pathways and associated therapeutic strategies

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this