Comment on “The [4Fe4S] cluster of human DNA primase functions as a redox switch using DNA charge transport”

Andrey G. Baranovskiy, Nigar D. Babayeva, Yinbo Zhang, Luis Blanco, Youri I. Pavlov, Tahir H. Tahirov

Research output: Contribution to journalComment/debate

9 Scopus citations

Abstract

O’Brien et al. (Research Article, 24 February 2017, eaag1789) proposed a novel mechanism of primase function based on redox activity of the iron-sulfur cluster buried inside the C-terminal domain of the large primase subunit (p58C). Serious problems in the experimental design and data interpretation raise concerns about the validity of the conclusions.

Original languageEnglish (US)
Article numbereaan2396
JournalScience
Volume357
Issue number6348
DOIs
StatePublished - Jul 21 2017

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