Comorbidities in rheumatoid arthritis

Kaleb Michaud, Frederick Wolfe

Research output: Contribution to journalReview articlepeer-review

310 Scopus citations


Rheumatoid arthritis (RA) is often characterized by the burden of swollen joints, pain, and decreased physical function, but less understood are the many manifestations of additional health conditions that are associated with RA and its treatments. First brought to light with observations of increased mortality in RA, studies noted the increased rates of cardiovascular and infection events. The chronic, debilitating, autoimmune nature of RA affects the patient directly or indirectly in almost all organ systems, from cardiovascular problems and infections to depression and gastrointestinal ulcers. On average, the established RA patient has two or more comorbid conditions. It should be the responsibility of the rheumatologist to take these and the risk of additional conditions into account when treating the patient. This chapter reviews important comorbidities in patients with RA, their prevalence, and their relation to RA.

Original languageEnglish (US)
Pages (from-to)885-906
Number of pages22
JournalBest Practice and Research: Clinical Rheumatology
Issue number5
StatePublished - Oct 2007


  • anti-TNF therapy
  • cardiovascular disease
  • comorbid condition
  • comorbidity
  • comorbidity index
  • infection
  • malignancy
  • outcomes
  • rheumatoid arthritis

ASJC Scopus subject areas

  • Rheumatology


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