TY - GEN
T1 - Comparative analysis of human and mouse CpG islands using dbCGI
AU - Yalcin, Dicle
AU - Otu, Hasan H.
N1 - Publisher Copyright:
© 2017 IEEE.
PY - 2017/9/27
Y1 - 2017/9/27
N2 - DNA methylation and histone modifications form the epigenetic code. Cytosine methylation maintains an inactive-condensed chromatin state and is involved in many cellular events such as gene expression, chromosomal stability, cell differentiation, and carcinogenesis. CpG islands (CGIs), which are stretches of DNA in vertebrate organisms with an over-representation of the CpG dinucleotide, are naturally unmethylated and play an important role in gene repression. There is a lack, however, of a CGI database that provides a comprehensive genome-wide analysis of the distribution and annotation of CGIs across organisms. We introduce dbCGI, a web-application that identifies, annotates, and analyzes CGIs. We performed individual genome-wide analysis of human and mouse CGIs in addition to a comparative analysis of the two organisms' CGIs using homologue gene pairs.
AB - DNA methylation and histone modifications form the epigenetic code. Cytosine methylation maintains an inactive-condensed chromatin state and is involved in many cellular events such as gene expression, chromosomal stability, cell differentiation, and carcinogenesis. CpG islands (CGIs), which are stretches of DNA in vertebrate organisms with an over-representation of the CpG dinucleotide, are naturally unmethylated and play an important role in gene repression. There is a lack, however, of a CGI database that provides a comprehensive genome-wide analysis of the distribution and annotation of CGIs across organisms. We introduce dbCGI, a web-application that identifies, annotates, and analyzes CGIs. We performed individual genome-wide analysis of human and mouse CGIs in addition to a comparative analysis of the two organisms' CGIs using homologue gene pairs.
KW - CpG island
KW - annotation
KW - epigenetics
KW - methylation
UR - http://www.scopus.com/inward/record.url?scp=85033681231&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85033681231&partnerID=8YFLogxK
U2 - 10.1109/EIT.2017.8053357
DO - 10.1109/EIT.2017.8053357
M3 - Conference contribution
AN - SCOPUS:85033681231
T3 - IEEE International Conference on Electro Information Technology
SP - 211
EP - 216
BT - 2017 IEEE International Conference on Electro Information Technology, EIT 2017
PB - IEEE Computer Society
T2 - 2017 IEEE International Conference on Electro Information Technology, EIT 2017
Y2 - 14 May 2017 through 17 May 2017
ER -