Comparative antimalarial activities of six pairs of 1,2,4,5-tetraoxanes (peroxide dimers) and 1,2,4,5,7,8-hexaoxonanes (peroxide trimers)

Yuxiang Dong, Darren Creek, Jacques Chollet, Hugues Matile, Susan A. Charman, Sergio Wittlin, James K. Wood, Jonathan L. Vennerstrom

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Six tetraoxanes had 50% inhibitory concentrations in the range of 10 to 100 ng/ml against Plasmodium falciparum, whereas the corresponding hexaoxonanes had minimal antimalarial activity. The lack of iron-mediated reactivity of the hexaoxonanes may explain their low activity compared to the tetraoxanes, the latter of which are able to undergo iron (II)-mediated activation.

Original languageEnglish (US)
Pages (from-to)3033-3035
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume51
Issue number8
DOIs
StatePublished - Aug 2007

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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