Comparative antimalarial activities of six pairs of 1,2,4,5-tetraoxanes (peroxide dimers) and 1,2,4,5,7,8-hexaoxonanes (peroxide trimers)

Yuxiang Dong; Darren Creek; Jacques Chollet; Hugues Matile; Susan A. Charman; Sergio Wittlin; James K. Wood; Jonathan L. Vennerstrom

doi:10.1128/AAC.00264-07

Comparative antimalarial activities of six pairs of 1,2,4,5-tetraoxanes (peroxide dimers) and 1,2,4,5,7,8-hexaoxonanes (peroxide trimers)

Yuxiang Dong, Darren Creek, Jacques Chollet, Hugues Matile, Susan A. Charman, Sergio Wittlin, James K. Wood, Jonathan L. Vennerstrom

Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Six tetraoxanes had 50% inhibitory concentrations in the range of 10 to 100 ng/ml against Plasmodium falciparum, whereas the corresponding hexaoxonanes had minimal antimalarial activity. The lack of iron-mediated reactivity of the hexaoxonanes may explain their low activity compared to the tetraoxanes, the latter of which are able to undergo iron (II)-mediated activation.

Original language	English (US)
Pages (from-to)	3033-3035
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	51
Issue number	8
DOIs	https://doi.org/10.1128/AAC.00264-07
State	Published - Aug 2007

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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AU - Dong, Yuxiang

AU - Creek, Darren

AU - Chollet, Jacques

AU - Matile, Hugues

AU - Charman, Susan A.

AU - Wittlin, Sergio

AU - Wood, James K.

AU - Vennerstrom, Jonathan L.

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Comparative antimalarial activities of six pairs of 1,2,4,5-tetraoxanes (peroxide dimers) and 1,2,4,5,7,8-hexaoxonanes (peroxide trimers)

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