TY - JOUR
T1 - Comparative Carcinogenicity in the Rat of 2-Hydrazinothiazoles with Nitrofuryl, Nitrophenyl, or Aminophenyl Substituents in the 4-Position
AU - Cohen, S. M.
AU - Ertürk, E.
AU - Price, J. M.
AU - Bryan, George T.
PY - 1970/4
Y1 - 1970/4
N2 - 2-Hydrazino-4-(5-nitro-2-furyl)thiazole, 2-(2,2-dimethylhydrazino)-4–(5-nitro-2-fury l)thiazole, 2-hydrazino-4-(4-nitro-phenyl)thiazole, and 2-hydrazino-4-(4-aminophenyl)thiazole were fed to female Sprague-Dawley rats, and all were found to be potent carcinogens. Each induced chiefly carcinomas of the mammary gland (32/35, 30/31, 27/34, 34/35, respectively), as well as a lower incidence of tumors of other organs. The carcinogenic relationship of these four compounds to formic acid 2-[4-(5-nitro-2-furyl)-2-thiazolyl]hydrazide is discussed.
AB - 2-Hydrazino-4-(5-nitro-2-furyl)thiazole, 2-(2,2-dimethylhydrazino)-4–(5-nitro-2-fury l)thiazole, 2-hydrazino-4-(4-nitro-phenyl)thiazole, and 2-hydrazino-4-(4-aminophenyl)thiazole were fed to female Sprague-Dawley rats, and all were found to be potent carcinogens. Each induced chiefly carcinomas of the mammary gland (32/35, 30/31, 27/34, 34/35, respectively), as well as a lower incidence of tumors of other organs. The carcinogenic relationship of these four compounds to formic acid 2-[4-(5-nitro-2-furyl)-2-thiazolyl]hydrazide is discussed.
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M3 - Article
C2 - 5537322
AN - SCOPUS:0014767070
SN - 0008-5472
VL - 30
SP - 897
EP - 901
JO - Cancer Research
JF - Cancer Research
IS - 4
ER -