TY - JOUR
T1 - Comparative carcinogenicity of formic acid 2-[4-(5-nitro-2-furyl)-2-thiazolyl] hydrazide and related chemicals in the rat
AU - Ertiirk, E.
AU - Morris, J. Emory
AU - Cohen, S. M.
AU - Von Esch, A. M.
AU - Crovetti, A. J.
AU - Price, J. M.
AU - Bryan, George T.
N1 - Funding Information:
GM 01932 from the National Institute of General Medical Sciences. 6 Division of Experimental Chemistry, AbbottLaboratories. 7 Division of Experimental Therapy. Abbott Laboratories. 8 Public Health Service Career Development Award l-K4-CA 8245 from the National Cancer Institute. D We thank Professor A. M. Pamukcu for independently reviewing and substantiating our histological interpretation of this material, Miss R. S. Leith for diet preparation and care of the rats, and Mrs. S. Pertzborn, Mrs. C. Schlotthauer, and Mrs. S. Pope for assisting in the preparation of the manuscript.
Funding Information:
1 Received March 2, 1971; accepted April 23, 1971. 2 Supported in part by Public Health Service research grant CA 11946 and contract PH 43-66-888, both from the National Cancer Institute, and by a grant from the Wisconsin Division, American Cancer Society, Inc. a Division of Clinical Oncology, University of Wisconsin Medical School. 4 Present address: Department of Chemistry, State University College at Brockport, Brockport, N.Y. 14420. 5 Medical Scientist Trainee, Public Health Service'grant
PY - 1971/8
Y1 - 1971/8
N2 - Formic acid 2 - [4-(5-nitro- 2 - furyl)-2-thiazolyI1 hydrazide (FNT) previously demonstrated a high degree of carcinogenic activity in Swiss mice and Holtzman female rats. In the present study, male and female Sprague-Dawley rats and female Buffalo rats were susceptible to the carcinogenic action of FNT, which induced at high incidences mammary, renal, and hepatic tumors and tumors at other sites. To determine possible tructural requirements for this activity, 2-hydrazino-4-(5-nitro-2-furyl)thiazole, formic acid 2-[4-(2-furyl)-2-thiazolyl]hydrazide, formic acid 2-(4-methyl-2-thiazolyl)hydrazide, or 1-formyl-3-thiosemicarbazide was fed to female Sprague-Dawley rats. In 26 rats at risk, FNT induced multiple mammary tumors in 25 rats, renal tumors in 22, liver tumors in 12, and a few tumors at other sites. In 16 rats at risk, 2-hydrazino-4-(5-nitro-2-furyl)thiazole induced multiple mammary tumors in 15 rats and renal tumors in 3. In contrast to the marked activity of these 2 compounds, formic acid 2-[4- (2-furyl)-2-thiazolyI1hydrazidet lacking the nitro group in the 5-position on the furan ring, induced 0 tumors in 23 rats, and 1-formyl-3-thiosemicarbazide induced 5 solitary mammary tumors in 27 rats (0.50>P>0.30) (2 of 29 control rats bore solitary mammary tumors), though growth was somewhat retarded with both compounds. Intermediate in activity, formic acid 2-(4- methyl-2-thiazolyl)hydrazide induced 8 solitary mammary tumors among 28 rats at risk (P=0.034). These data suggest the nitro group in the 5- position of the furan ring plays a major, but perhaps not exclusive, role in the carcinogenic action of FNT and 2-hydrazino-4-(5-nifro-2-furyl)thiazole.- J Nat Cancer Inst 47: 437-445, 1971.
AB - Formic acid 2 - [4-(5-nitro- 2 - furyl)-2-thiazolyI1 hydrazide (FNT) previously demonstrated a high degree of carcinogenic activity in Swiss mice and Holtzman female rats. In the present study, male and female Sprague-Dawley rats and female Buffalo rats were susceptible to the carcinogenic action of FNT, which induced at high incidences mammary, renal, and hepatic tumors and tumors at other sites. To determine possible tructural requirements for this activity, 2-hydrazino-4-(5-nitro-2-furyl)thiazole, formic acid 2-[4-(2-furyl)-2-thiazolyl]hydrazide, formic acid 2-(4-methyl-2-thiazolyl)hydrazide, or 1-formyl-3-thiosemicarbazide was fed to female Sprague-Dawley rats. In 26 rats at risk, FNT induced multiple mammary tumors in 25 rats, renal tumors in 22, liver tumors in 12, and a few tumors at other sites. In 16 rats at risk, 2-hydrazino-4-(5-nitro-2-furyl)thiazole induced multiple mammary tumors in 15 rats and renal tumors in 3. In contrast to the marked activity of these 2 compounds, formic acid 2-[4- (2-furyl)-2-thiazolyI1hydrazidet lacking the nitro group in the 5-position on the furan ring, induced 0 tumors in 23 rats, and 1-formyl-3-thiosemicarbazide induced 5 solitary mammary tumors in 27 rats (0.50>P>0.30) (2 of 29 control rats bore solitary mammary tumors), though growth was somewhat retarded with both compounds. Intermediate in activity, formic acid 2-(4- methyl-2-thiazolyl)hydrazide induced 8 solitary mammary tumors among 28 rats at risk (P=0.034). These data suggest the nitro group in the 5- position of the furan ring plays a major, but perhaps not exclusive, role in the carcinogenic action of FNT and 2-hydrazino-4-(5-nifro-2-furyl)thiazole.- J Nat Cancer Inst 47: 437-445, 1971.
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U2 - 10.1093/jnci/47.2.437
DO - 10.1093/jnci/47.2.437
M3 - Article
C2 - 5559244
AN - SCOPUS:0015107545
SN - 0027-8874
VL - 47
SP - 437
EP - 445
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
IS - 2
ER -