Comparative manufacture and cell-based delivery of antiretroviral nanoformulations.

Shantanu Balkundi, Ari S. Nowacek, Ram S. Veerubhotla, Han Chen, Andrea Martinez-Skinner, Upal Roy, R. Lee Mosley, Georgette Kanmogne, Xinming Liu, Alexander V. Kabanov, Tatiana Bronich, Jo Ellyn McMillan, Howard E. Gendelman

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Nanoformulations of crystalline indinavir, ritonavir, atazanavir, and efavirenz were manufactured by wet milling, homogenization or sonication with a variety of excipients. The chemical, biological, immune, virological, and toxicological properties of these formulations were compared using an established monocyte-derived macrophage scoring indicator system. Measurements of drug uptake, retention, release, and antiretroviral activity demonstrated differences amongst preparation methods. Interestingly, for drug cell targeting and antiretroviral responses the most significant difference among the particles was the drug itself. We posit that the choice of drug and formulation composition may ultimately affect clinical utility.

Original languageEnglish (US)
Pages (from-to)3393-3404
Number of pages12
JournalInternational journal of nanomedicine
Volume6
StatePublished - 2011

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Comparative manufacture and cell-based delivery of antiretroviral nanoformulations.'. Together they form a unique fingerprint.

  • Cite this

    Balkundi, S., Nowacek, A. S., Veerubhotla, R. S., Chen, H., Martinez-Skinner, A., Roy, U., Mosley, R. L., Kanmogne, G., Liu, X., Kabanov, A. V., Bronich, T., McMillan, J. E., & Gendelman, H. E. (2011). Comparative manufacture and cell-based delivery of antiretroviral nanoformulations. International journal of nanomedicine, 6, 3393-3404.