Comparative pathology of proliferative lesions of the urinary bladder

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

Bladder neoplasia in humans consists of 2 diseases, a low-grade papillary tumor that does not invade or metastasize, and a high-grade lesion that usually invades and metastasizes. Bladder carcinogenesis in rats is most like the low-grade, papillary tumor, although it eventually does progress and invade. In the mouse, models are available that mimic each of these disease processes. Preneoplastic lesions in humans and rodents include various types of hyperplasia, proliferative cystitis, and dysplasia. These preneoplastic and neoplastic lesions arise throughout the urothelium, from the renal pelvis to the urethra, although most commonly in the bladder. Rarely, benign and malignant mesenchymal lesions occur in rats and mice, with a unique submucosal mesenchymal lesion present in some strains of mice. In addition, eosinophilic and clear inclusions in the superficial layer of urothelium in mice, which do not appear to be associated with toxicity or carcinogenesis, have been reported. An approach to evaluation of carcinogenic mechanisms involved in the urothelium is presented. It focuses on distinguishing between DNA reactive carcinogens vs those that act by increasing cell proliferation. Although rodent models do not precisely mimic the human disease, they have provided useful models for furthering our understanding of the carcinogenic process in the urothelium as it pertains to human diseases.

Original languageEnglish (US)
Pages (from-to)663-671
Number of pages9
JournalToxicologic Pathology
Volume30
Issue number6
DOIs
StatePublished - Nov 2002

Keywords

  • Bladder
  • Carcinoma
  • Dysplasia
  • Hyperplasia
  • Papilloma
  • Pathology
  • Urothelium

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Toxicology
  • Cell Biology

Fingerprint Dive into the research topics of 'Comparative pathology of proliferative lesions of the urinary bladder'. Together they form a unique fingerprint.

  • Cite this