Comparative trial of oral clotrimazole and nystatin for oropharyngeal candidiasis prophylaxis in orthotopic liver transplant patients

James D. Ruskin, R. Patrick Wood, Michael R. Bailey, Cherie K. Whitmore, Byers W. Shaw

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

A prospective randomized study was conducted to assess the effectiveness of clotrimazole troches and nystatin suspension to prevent oral candidiasis in immunosuppressed orthotopic liver transplant patients. Thirty-four patients received either clotrimazole troches, 10 mg, five times daily, or nystatin suspension, 500,000 units, four times daily. Prophylaxis was initiated after extubation after transplantation and continued throughout the hospitalization. One of 17 patients in each treatment group developed clinical and microscopic evidence of an oropharyngealCandida infection. This gave an intragroup and an overall infection rate of 5.9%. It appears that either nystatin or clotrimazole may be used for candidiasis prophylaxis in orthotopic liver transplant patients.

Original languageEnglish (US)
Pages (from-to)567-571
Number of pages5
JournalOral Surgery, Oral Medicine, Oral Pathology
Volume74
Issue number5
DOIs
StatePublished - Nov 1992
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Dentistry(all)

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