Comparing biocompatibility of titanium orthopaedic implants with and without an ultra-thin coating of TiO2 by Ion beam assisted deposition

R. Miralami, F. Namavar, G. M. Thiele, J. G. Sharp, K. L. Garvin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The evaluation of the biocompatibility of orthopaedic implants is a main factor in the validating their healing potential. Titanium (Ti) has this unique trait along with other reliable mechanical properties, which makes it a perfect choice for orthopaedic purposes. Namavar et al. employed ion beam assisted deposition (IBAD) technique to coat a thin nano-layer of titanium oxide over different surfaces in order to increase their osseointegration properties. To compare the properties of the newly engineered nano-crystalline TiO2 surface with bulk Ti, we have studied the osteoblast functions and cellular responses on these surfaces-including adhesion, growth, and mineralization-using a human osteoblast-like cell line (SAOS-2). The correlation between surface properties and cellular responses was studied using immunofluorescence techniques and alizarin red assay. The result of this study indicated that nano-engineered TiO2 surface is superior in supporting of cellular responses of bone-forming cells as compared to orthopaedic grade Ti.

Original languageEnglish (US)
Title of host publicationBiotech, Biomaterials and Biomedical - TechConnect Briefs 2016
EditorsMatthew Laudon, Fiona Case, Fiona Case, Bart Romanowicz, Bart Romanowicz
PublisherTechConnect
Pages43-46
Number of pages4
ISBN (Electronic)9780997511727
StatePublished - 2016
Event10th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 19th Annual Nanotech Conference and Expo, and the 2016 National SBIR/STTR Conference - Washington, United States
Duration: May 22 2016May 25 2016

Publication series

NameAdvanced Materials - TechConnect Briefs 2016
Volume3

Other

Other10th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 19th Annual Nanotech Conference and Expo, and the 2016 National SBIR/STTR Conference
CountryUnited States
CityWashington
Period5/22/165/25/16

Keywords

  • Biocompatibility
  • Biomaterial
  • Ion beam assisted deposition
  • Nanostructure
  • Orthopaedic

ASJC Scopus subject areas

  • Fluid Flow and Transfer Processes
  • Biotechnology
  • Surfaces, Coatings and Films
  • Fuel Technology

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