Comparison of a rapid hepatitis B immunization schedule to the standard schedule for adults

Luis S. Marsano, Richard N. Greenberg, Robert B. Kirkpatrick, Rowen K. Zetterman, Abigail Christiansen, Daniel J. Smith, Maria D. DeMedina, Eugene R. Schiff

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


We report a prospective, randomized, single-blinded trial comparing immunogenicity of rapid (0, 1, and 2 months) versus standard schedule (0, 1, 6 months) hepatitis B vaccinations of healthy adults with recombinant hepatitis B vaccine (Engerix-B, 20 μg i.m.) Volunteers (230 of 234) negative to hepatitis B were randomized and completed the study. Groups were similar in age, weight, race, and obesity rate, but the rapid schedule group had more women. Both groups reached ≥100 mIU/mL at a similar rate, but a higher seroprotection rate at ≥500 mIU/mL was reached by the standard schedule. No demographic variables influenced the effect of dose schedule on anti- hepatitis B titer. We conclude that rapid schedule vaccination gives a rate that is quicker than, and identical to, the rate of seroprotection of the standard schedule vaccination.

Original languageEnglish (US)
Pages (from-to)111-115
Number of pages5
JournalAmerican Journal of Gastroenterology
Issue number1
StatePublished - Jan 1996
Externally publishedYes

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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