Comparison of time domain and spectral domain optical coherence tomography in measurement of macular thickness in macular edema secondary to diabetic retinopathy and retinal vein occlusion

Elham Hatef, Afsheen Khwaja, Zubir Rentiya, Mohamed Ibrahim, Matthew Shulman, Peykan Turkcuoglu, Yasir Sepah, Jianmin Wang, Roomasa Channa, Millena Bittencourt, Abeer Akhtar, Jangwon Heo, Diana V. Do, Quan Dong Nguyen

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20 Scopus citations

Abstract

Purpose. To evaluate macular thickness, agreement, and intraclass repeatability in three optical coherence tomography (OCT) devices: the time domain (TD) Stratus OCT and two spectral domain (SD) OCTs, Spectralis and Cirrus SD-OCT, in eyes with macular edema secondary to diabetic retinopathy (DR) and retinal vein occlusion (VO). Methods. In a prospective observational study at a university-based retina practice, retinal thickness tomography was performed simultaneously for fifty-eight patients (91 eyes) with DR and VO employing a time domain and two spectral domain OCTs. Agreement in macular measurements was assessed by constructing Bland-Altman plots. Intraclass repeatability was assessed by intraclass correlation coefficients (ICCs). Results. Based on the Bland-Altman plots for central macular thickness, there was low agreement between the measurements of Cirrus SD-OCT and Stratus OCT, Spectralis OCT and Stratus OCT, as well as Spectralis OCT and Cirrus SD-OCT among DR and RVO patients. All three devices demonstrated high intraclass repeatability, with ICC of 98% for Stratus OCT, 97% for Cirrus SD-OCT, and 100% for Spectralis OCT among DR patients. The ICC was 97% for Stratus OCT, 79% for Cirrus SD-OCT, and 91% for Spectralis OCT among RVO patients. Conclusion. There are low agreements among interdevice measurements. However, intraclass repeatability is high in both TD and SD-OCT devices.

Original languageEnglish (US)
Article number354783
JournalJournal of Ophthalmology
Volume2012
DOIs
StatePublished - Dec 1 2012

ASJC Scopus subject areas

  • Ophthalmology

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    Hatef, E., Khwaja, A., Rentiya, Z., Ibrahim, M., Shulman, M., Turkcuoglu, P., Sepah, Y., Wang, J., Channa, R., Bittencourt, M., Akhtar, A., Heo, J., Do, D. V., & Nguyen, Q. D. (2012). Comparison of time domain and spectral domain optical coherence tomography in measurement of macular thickness in macular edema secondary to diabetic retinopathy and retinal vein occlusion. Journal of Ophthalmology, 2012, [354783]. https://doi.org/10.1155/2012/354783