Competitive inhibition of brain hexokinase by metrizamide

John M. Bertoni, Charles G. Steinman

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

We compared the effect of metrizamide and its parent compound glucosamine on the kinetics of dog brain hexokinase. The Michaelis constant (Km) for glucose rose from 0.065 to 0.15 to 0.28 mM in the presence of 0, 16, and 32 mM metrizamide, respectively. For 0, 1.5, and 3.7 mM glucosamine, the Km values were 0.065, 0.4, and 1.3 mM. No change was found in the maximal velocity with either inhibitor. Metrizamide is therefore a rather weak competitive inhibitor of brain hexokinase. However, since the brain or spinal cord may be exposed to metrizamide concentrations near 780 mM during myelography, it is predictable that glucose metabolism may be significantly impaired under these conditions. This may be the mechanism for some cases of metrizamide encephalopathy.

Original languageEnglish (US)
Pages (from-to)320-323
Number of pages4
JournalNeurology
Volume32
Issue number3
DOIs
StatePublished - Mar 1982

ASJC Scopus subject areas

  • Clinical Neurology

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