Competitive NMDA receptor blockers reduce striatal glutamate accumulation in ischaemia

Othman Ghribi, Jacques Callebert, Michel Plotkine, Roger G. Boulu

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Our previous studies have shown that kynurenic acid, a broad-spectrum antagonist of excitatory amino acid receptors, depressed the ischaemia-induced accumulation of glutamate and aspartate in rat striatum. In the present experiments we examined the effect of two competitive N-methyl-D-aspartate (NMDA) receptor antagonists on striatal extracellular glutamate concentrations induced by a 30 min ‘4-vessel occlusion’ ischaemia in rats. Local perfusion with 2-amino-5-phosphonovalerate (AP5; 300,μM) and with 2-amino-7-phosphonoheptanoate (AP7; 300 μM), using a microdialysis fibre markedly reduced the ischaemia-induced increase in glutamate concentrations. These results indicate that, during forebrain ischaemia the NMDA receptor type mediates glutamate and aspartate accumulation in rat striatum.

Original languageEnglish (US)
Pages (from-to)1253-1255
Number of pages3
JournalNeuroReport
Volume5
Issue number10
DOIs
StatePublished - Jun 1994

Keywords

  • Aspartate
  • Forebrain ischaemia
  • Glutamate
  • NMDA receptor
  • Striatum

ASJC Scopus subject areas

  • Neuroscience(all)

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