Competitive NMDA receptor blockers reduce striatal glutamate accumulation in ischaemia

Othman Ghribi; Jacques Callebert; Michel Plotkine; Roger G. Boulu

doi:10.1097/00001756-199406020-00024

Competitive NMDA receptor blockers reduce striatal glutamate accumulation in ischaemia

Othman Ghribi, Jacques Callebert, Michel Plotkine, Roger G. Boulu

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Our previous studies have shown that kynurenic acid, a broad-spectrum antagonist of excitatory amino acid receptors, depressed the ischaemia-induced accumulation of glutamate and aspartate in rat striatum. In the present experiments we examined the effect of two competitive N-methyl-D-aspartate (NMDA) receptor antagonists on striatal extracellular glutamate concentrations induced by a 30 min ‘4-vessel occlusion’ ischaemia in rats. Local perfusion with 2-amino-5-phosphonovalerate (AP5; 300,μM) and with 2-amino-7-phosphonoheptanoate (AP7; 300 μM), using a microdialysis fibre markedly reduced the ischaemia-induced increase in glutamate concentrations. These results indicate that, during forebrain ischaemia the NMDA receptor type mediates glutamate and aspartate accumulation in rat striatum.

Original language	English (US)
Pages (from-to)	1253-1255
Number of pages	3
Journal	NeuroReport
Volume	5
Issue number	10
DOIs	https://doi.org/10.1097/00001756-199406020-00024
State	Published - Jun 1994
Externally published	Yes

Keywords

Aspartate
Forebrain ischaemia
Glutamate
NMDA receptor
Striatum

ASJC Scopus subject areas

Neuroscience(all)

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10.1097/00001756-199406020-00024

Cite this

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title = "Competitive NMDA receptor blockers reduce striatal glutamate accumulation in ischaemia",

abstract = "Our previous studies have shown that kynurenic acid, a broad-spectrum antagonist of excitatory amino acid receptors, depressed the ischaemia-induced accumulation of glutamate and aspartate in rat striatum. In the present experiments we examined the effect of two competitive N-methyl-D-aspartate (NMDA) receptor antagonists on striatal extracellular glutamate concentrations induced by a 30 min {\textquoteleft}4-vessel occlusion{\textquoteright} ischaemia in rats. Local perfusion with 2-amino-5-phosphonovalerate (AP5; 300,μM) and with 2-amino-7-phosphonoheptanoate (AP7; 300 μM), using a microdialysis fibre markedly reduced the ischaemia-induced increase in glutamate concentrations. These results indicate that, during forebrain ischaemia the NMDA receptor type mediates glutamate and aspartate accumulation in rat striatum.",

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author = "Othman Ghribi and Jacques Callebert and Michel Plotkine and Boulu, {Roger G.}",

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AU - Ghribi, Othman

AU - Callebert, Jacques

AU - Plotkine, Michel

AU - Boulu, Roger G.

PY - 1994/6

Y1 - 1994/6

N2 - Our previous studies have shown that kynurenic acid, a broad-spectrum antagonist of excitatory amino acid receptors, depressed the ischaemia-induced accumulation of glutamate and aspartate in rat striatum. In the present experiments we examined the effect of two competitive N-methyl-D-aspartate (NMDA) receptor antagonists on striatal extracellular glutamate concentrations induced by a 30 min ‘4-vessel occlusion’ ischaemia in rats. Local perfusion with 2-amino-5-phosphonovalerate (AP5; 300,μM) and with 2-amino-7-phosphonoheptanoate (AP7; 300 μM), using a microdialysis fibre markedly reduced the ischaemia-induced increase in glutamate concentrations. These results indicate that, during forebrain ischaemia the NMDA receptor type mediates glutamate and aspartate accumulation in rat striatum.

AB - Our previous studies have shown that kynurenic acid, a broad-spectrum antagonist of excitatory amino acid receptors, depressed the ischaemia-induced accumulation of glutamate and aspartate in rat striatum. In the present experiments we examined the effect of two competitive N-methyl-D-aspartate (NMDA) receptor antagonists on striatal extracellular glutamate concentrations induced by a 30 min ‘4-vessel occlusion’ ischaemia in rats. Local perfusion with 2-amino-5-phosphonovalerate (AP5; 300,μM) and with 2-amino-7-phosphonoheptanoate (AP7; 300 μM), using a microdialysis fibre markedly reduced the ischaemia-induced increase in glutamate concentrations. These results indicate that, during forebrain ischaemia the NMDA receptor type mediates glutamate and aspartate accumulation in rat striatum.

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KW - NMDA receptor

KW - Striatum

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Competitive NMDA receptor blockers reduce striatal glutamate accumulation in ischaemia

Abstract

Keywords

ASJC Scopus subject areas

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