Abstract
Our previous studies have shown that kynurenic acid, a broad-spectrum antagonist of excitatory amino acid receptors, depressed the ischaemia-induced accumulation of glutamate and aspartate in rat striatum. In the present experiments we examined the effect of two competitive N-methyl-D-aspartate (NMDA) receptor antagonists on striatal extracellular glutamate concentrations induced by a 30 min ‘4-vessel occlusion’ ischaemia in rats. Local perfusion with 2-amino-5-phosphonovalerate (AP5; 300,μM) and with 2-amino-7-phosphonoheptanoate (AP7; 300 μM), using a microdialysis fibre markedly reduced the ischaemia-induced increase in glutamate concentrations. These results indicate that, during forebrain ischaemia the NMDA receptor type mediates glutamate and aspartate accumulation in rat striatum.
Original language | English (US) |
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Pages (from-to) | 1253-1255 |
Number of pages | 3 |
Journal | NeuroReport |
Volume | 5 |
Issue number | 10 |
DOIs | |
State | Published - Jun 1994 |
Externally published | Yes |
Keywords
- Aspartate
- Forebrain ischaemia
- Glutamate
- NMDA receptor
- Striatum
ASJC Scopus subject areas
- General Neuroscience