Complex roles of neutrophils during arboviral infections

Abenaya Muralidharan, St Patrick Reid

Research output: Contribution to journalReview articlepeer-review

Abstract

Arboviruses are known to cause large-scale epidemics in many parts of the world. These arthropod-borne viruses are a large group consisting of viruses from a wide range of families. The ability of their vector to enhance viral pathogenesis and transmission makes the development of treatments against these viruses challenging. Neutrophils are generally the first leukocytes to be recruited to a site of infection, playing a major role in regulating inflammation and, as a result, viral replication and dissemination. However, the underlying mechanisms through which neutrophils control the progression of inflammation and disease remain to be fully understood. In this review, we highlight the major findings from recent years regarding the role of neutrophils during arboviral infections. We discuss the complex nature of neutrophils in mediating not only protection, but also augmenting disease pathology. Better understanding of neutrophil pathways involved in effective protection against arboviral infections can help identify potential targets for therapeutics.

Original languageEnglish (US)
Article number1324
JournalCells
Volume10
Issue number6
DOIs
StatePublished - Jun 2021

Keywords

  • Arboviruses
  • Inflammation
  • Mosquito
  • Neutrophils
  • Pathology

ASJC Scopus subject areas

  • Medicine(all)

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