TY - JOUR
T1 - Complex secondary chromosome abnormalities in advanced stage anaplastic large cell lymphoma of children and adolescents
T2 - a report from CCG-E08
AU - Lones, Mark A.
AU - Heerema, Nyla A.
AU - Le Beau, Michelle M.
AU - Perkins, Sherrie L.
AU - Kadin, Marshall E.
AU - Kjeldsberg, Carl R.
AU - Sposto, Richard
AU - Meadows, Anna
AU - Siegel, Stuart
AU - Buckley, Jonathan
AU - Finlay, Jonathan
AU - Abromowitch, Minnie
AU - Cairo, Mitchell S.
AU - Sanger, Warren G.
N1 - Funding Information:
The authors appreciate the grant support from the Division of Cancer Treatment, National Cancer Institute, National Institutes of Health, and the Department of Health and Human Services, including Children's Cancer Group grant CA 13539 and Children's Oncology Group grant CA 98543. (A complete listing of grant support for research conducted by the Children's Cancer Group and the Pediatric Oncology Group before initiation of the Children's Oncology Group grant in 2003 is available online at http://www.childrensoncologygroup.org/admin/grantinfo.htm .) We also appreciate the assistance of Donna Correia and Roxanne Hernandez of the Children's Oncology Group Publications Office with this manuscript.
PY - 2006/12
Y1 - 2006/12
N2 - Among pediatric non-Hodgkin lymphomas, one of the most distinctive types is anaplastic large cell lymphoma (ALCL). Specific chromosomal abnormalities are associated with prognosis in childhood acute lymphoblastic leukemia, but chromosome abnormalities have not been evaluated for prognostic value in pediatric ALCL. For Children's Cancer Group protocol CCG-E-08 Etiologic Study of Non-Hodgkin Lymphoma in Childhood, three patients were enrolled with cytogenetic analysis of ALCL and simultaneously enrolled on treatment protocol CCG-552. Pathology material and karyotypes at initial diagnosis underwent central review. Demographics included ages of 9, 12, and 14 years, and a male/female ratio of 1:2. All patients had advanced disease (stage III). Disease progressed or relapsed in two patients, and one died. Chromosomal abnormalities, including t(2;5)(p23;q35), the ALK/NPM fusion gene, and complex karyotypes with multiple additional abnormalities, were identified in all three patients. In two patients with progressive disease or relapse, additional chromosomal abnormalities at 1q21 and 10q24, possibly involving MCL1 and HOX11/TCL3, respectively, may have contributed to worse outcome. Pediatric ALCL cases frequently have complex karyotypes and usually involve ALK/NPM translocations in this limited study. Additional chromosome abnormalities may be involved in the pathogenesis of ALCL. Further studies are warranted in larger cohorts of children and adolescents with ALCL.
AB - Among pediatric non-Hodgkin lymphomas, one of the most distinctive types is anaplastic large cell lymphoma (ALCL). Specific chromosomal abnormalities are associated with prognosis in childhood acute lymphoblastic leukemia, but chromosome abnormalities have not been evaluated for prognostic value in pediatric ALCL. For Children's Cancer Group protocol CCG-E-08 Etiologic Study of Non-Hodgkin Lymphoma in Childhood, three patients were enrolled with cytogenetic analysis of ALCL and simultaneously enrolled on treatment protocol CCG-552. Pathology material and karyotypes at initial diagnosis underwent central review. Demographics included ages of 9, 12, and 14 years, and a male/female ratio of 1:2. All patients had advanced disease (stage III). Disease progressed or relapsed in two patients, and one died. Chromosomal abnormalities, including t(2;5)(p23;q35), the ALK/NPM fusion gene, and complex karyotypes with multiple additional abnormalities, were identified in all three patients. In two patients with progressive disease or relapse, additional chromosomal abnormalities at 1q21 and 10q24, possibly involving MCL1 and HOX11/TCL3, respectively, may have contributed to worse outcome. Pediatric ALCL cases frequently have complex karyotypes and usually involve ALK/NPM translocations in this limited study. Additional chromosome abnormalities may be involved in the pathogenesis of ALCL. Further studies are warranted in larger cohorts of children and adolescents with ALCL.
UR - http://www.scopus.com/inward/record.url?scp=33751004996&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33751004996&partnerID=8YFLogxK
U2 - 10.1016/j.cancergencyto.2006.04.019
DO - 10.1016/j.cancergencyto.2006.04.019
M3 - Article
C2 - 17116485
AN - SCOPUS:33751004996
SN - 0165-4608
VL - 171
SP - 89
EP - 96
JO - Cancer genetics and cytogenetics
JF - Cancer genetics and cytogenetics
IS - 2
ER -