Composite living fibers for creating tissue constructs using textile techniques

Mohsen Akbari, Ali Tamayol, Veronique Laforte, Nasim Annabi, Alireza Hassani Najafabadi, Ali Khademhosseini, David Juncker

Research output: Contribution to journalArticle

88 Scopus citations


The fabrication of cell-laden structures with anisotropic mechanical properties while having a precise control over the distribution of different cell types within the constructs is important for many tissue engineering applications. Automated textile technologies for making fabrics allow simultaneous control over the color pattern and directional mechanical properties. The use of textile techniques in tissue engineering, however, demands the presence of cell-laden fibers that can withstand the mechanical stresses during the assembly process. Here, the concept of composite living fibers (CLFs) in which a core of load bearing synthetic polymer is coated by a hydrogel layer containing cells or microparticles is introduced. The core thread is drawn sequentially through reservoirs containing a cell-laden prepolymer and a crosslinking reagent. The thickness of the hydrogel layer increases linearly with to the drawing speed and the prepolymer viscosity. CLFs are fabricated and assembled using regular textile processes including weaving, knitting, braiding, winding, and embroidering, to form cell-laden structures. Cellular viability and metabolic activity are preserved during CLF fabrication and assembly, demonstrating the feasibility of using these processes for engineering functional 3D tissue constructs.

Original languageEnglish (US)
Pages (from-to)4060-4067
Number of pages8
JournalAdvanced Functional Materials
Issue number26
StatePublished - Jul 9 2014


  • fiber-based techniques
  • living fibers
  • textile technology
  • tissue engineering
  • weaving

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

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  • Cite this

    Akbari, M., Tamayol, A., Laforte, V., Annabi, N., Najafabadi, A. H., Khademhosseini, A., & Juncker, D. (2014). Composite living fibers for creating tissue constructs using textile techniques. Advanced Functional Materials, 24(26), 4060-4067.