Abstract
γ-Glutamyl peptides (γ-GPs) are a group of peptides naturally found in various food sources. The unique γ-bond potentially enables them to resist gastrointestinal digestion and offers high stability in vivo with a longer half-life. In recent years, these peptides have caught researchers' attention due to their ability to impart kokumi taste and elicit various physiological functions via the allosteric activation of the calcium-sensing receptor (CaSR). This review discusses the various food sources of γ-glutamyl peptides, different synthesis modes, allosteric activation of CaSR for taste perception, and associated multiple biological functions they can exhibit, with a special emphasis on their role in modulating chronic inflammation concerning cardiovascular health.
Original language | English (US) |
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Pages (from-to) | 7851-7870 |
Number of pages | 20 |
Journal | Journal of Agricultural and Food Chemistry |
Volume | 70 |
Issue number | 26 |
DOIs | |
State | Published - Jul 6 2022 |
Keywords
- cardiovascular diseases
- CaSR
- dietary peptides
- inflammation
- γ-glutamyl peptides
ASJC Scopus subject areas
- General Chemistry
- General Agricultural and Biological Sciences