Comprehensive Review of γ-Glutamyl Peptides (γ-GPs) and Their Effect on Inflammation Concerning Cardiovascular Health

Snigdha Guha, Kaustav Majumder

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

γ-Glutamyl peptides (γ-GPs) are a group of peptides naturally found in various food sources. The unique γ-bond potentially enables them to resist gastrointestinal digestion and offers high stability in vivo with a longer half-life. In recent years, these peptides have caught researchers' attention due to their ability to impart kokumi taste and elicit various physiological functions via the allosteric activation of the calcium-sensing receptor (CaSR). This review discusses the various food sources of γ-glutamyl peptides, different synthesis modes, allosteric activation of CaSR for taste perception, and associated multiple biological functions they can exhibit, with a special emphasis on their role in modulating chronic inflammation concerning cardiovascular health.

Original languageEnglish (US)
Pages (from-to)7851-7870
Number of pages20
JournalJournal of Agricultural and Food Chemistry
Volume70
Issue number26
DOIs
StatePublished - Jul 6 2022

Keywords

  • cardiovascular diseases
  • CaSR
  • dietary peptides
  • inflammation
  • γ-glutamyl peptides

ASJC Scopus subject areas

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)

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