Comprehensive two-dimensional gas chromatography and food sensory properties: Potential and challenges

Chiara Cordero, Johannes Kiefl, Peter Schieberle, Stephen E. Reichenbach, Carlo Bicchi

Research output: Contribution to journalReview articlepeer-review

80 Scopus citations


Modern omics disciplines dealing with food flavor focus the analytical efforts on the elucidation of sensory-active compounds, including all possible stimuli of multimodal perception (aroma, taste, texture, etc.) by means of a comprehensive, integrated treatment of sample constituents, such as physicochemical properties, concentration in the matrix, and sensory properties (odor/taste quality, perception threshold). Such analyses require detailed profiling of known bioactive components as well as advanced fingerprinting techniques to catalog sample constituents comprehensively, quantitatively, and comparably across samples. Multidimensional analytical platforms support comprehensive investigations required for flavor analysis by combining information on analytes' identities, physicochemical behaviors (volatility, polarity, partition coefficient, and solubility), concentration, and odor quality. Unlike other omics, flavor metabolomics and sensomics include the final output of the biological phenomenon (i.e., sensory perceptions) as an additional analytical dimension, which is specifically and exclusively triggered by the chemicals analyzed. However, advanced omics platforms, which are multidimensional by definition, pose challenging issues not only in terms of coupling with detection systems and sample preparation, but also in terms of data elaboration and processing. The large number of variables collected during each analytical run provides a high level of information, but requires appropriate strategies to exploit fully this potential. This review focuses on advances in comprehensive two-dimensional gas chromatography and analytical platforms combining two-dimensional gas chromatography with olfactometry, chemometrics, and quantitative assays for food sensory analysis to assess the quality of a given product. We review instrumental advances and couplings, automation in sample preparation, data elaboration, and a selection of applications.

Original languageEnglish (US)
Pages (from-to)169-191
Number of pages23
JournalAnalytical and Bioanalytical Chemistry
Issue number1
StatePublished - Jan 1 2015


  • Comprehensive two-dimensional gas chromatography
  • Food aroma
  • Gas chromatography-olfactometry
  • High concentration capacity headspace techniques
  • Multidimensional gas chromatography
  • Sensomics

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry


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